Results 41 to 50 of about 373,786 (270)
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Transforming, Transgressing and Terrorizing
Religionsvidenskabeligt Tidsskrift, 2022 : The article discusses some werewolf motifs in Swedish ballads, which tell of shapeshifters of ambiguous character that change between a human and a non-human body, dwell in spaces on the fringe of the human world, and have potential to intrude into the
Catharina Raudvere
doaj +1 more source
Demography Is Not Destiny, Revisited [PDF]
, 2005 Looks at the impending demographic challenges of the aging American population. Considers the impact of factors in addition to anticipated changes in the size and age distribution, particularly those related to the economy and public ...
Laura Summer, Robert B. Friedland
core
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
A fluorescing spot on the temple: a helpful reminder for a detailed history and physical exam [PDF]
, 2019 We discuss a woman with a history of non-melanoma skin cancer who presented with a new erythematous macule on her right temple. On examination with Wood lamp the well-demarcated macule fluoresced pink making neoplasm unlikely.
Neiner, Destiny +3 more
core
FEBS Open Bio, EarlyView.Excess Ca2+ ions activate the Calcium‐Sensing Receptor (CaSR), which subsequently drives the uptake of excess inorganic phosphate (Pi) via the Pi transporter (Pit−1) in chondrocytes. This mechanism causes a toxic increase in intracellular Pi concentration, ultimately leading to chondrocyte apoptosis and pathological mineralization. Excess extracellular
Sachie Nakatani +7 more
wiley +1 more source
Theological Assessment of Teachers’ Perceptions of Destiny
Van İlahiyat Dergisi, 2023 It is known that issues related to destiny are among the most vivid questions and problems of religious thought and life. As far as the history of Islamic thought is concerned, it is seen that some differences of approach regarding destiny have been ...
Samet Karahüseyin, Mehmet Kenan Şahin
doaj +1 more source
Naked cuticle is essential for Drosophila wing development beyond Wingless signaling
FEBS Open Bio, EarlyView.Naked cuticle (Nkd), a Wnt signaling inhibitor, assumes extensive roles in Drosophila wing development. Overexpressing Nkd causes smaller, crumpled wings, while also perturbing multiple signaling pathways and developmental genes. A specific region (R1S) is critical for Nkd's function as a signaling integrator, offering new insights for studying its ...
Rui Wang, Ping Wang
wiley +1 more source
, 1998 A brief reconstruction of the birth, rise and ironical destiny of an almost universal expansion to other disciplines going with a dissolution within the original birthplace of the conception of an economic man, a male-only abstraction forgetful of its ...
Cremaschi, Sergio Volodia Marcello
core
FEBS Open Bio, EarlyView.This review provides an overview of bio‐based polymer sources, their unique functional properties and their environmental impact, and addresses their role as sustainable alternatives. It discusses end‐of‐life options, including composting and anaerobic digestion for renewable energy.
Sabina Kolbl Repinc +8 more
wiley +1 more source