Results 51 to 60 of about 631,552 (304)

A Robust Approach to Optimal Matched Filter Design in Ultrasonic Non-Destructive Evaluation (NDE) [PDF]

open access: yes, 2016
The matched filter was demonstrated to be a powerful yet efficient technique to enhance defect detection and imaging in ultrasonic non-destructive evaluation (NDE) of coarse grain materials, provided that the filter was properly designed and optimized ...
Hayward, Gordon, Li, Minghui
core   +3 more sources

AAA+ protein unfoldases—the Moirai of the proteome

open access: yesFEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Facing the Dark Side: How Leadership Destroys Organisational Innovation

open access: yesJournal of Technology Management & Innovation, 2019
Leadership is an essential element for promoting innovation. The literature has primarily focused on the effect of “constructive” leadership on innovation, although numerous studies point out that destructive leadership affects organizational performance.
Paulo Lopes Henriques   +3 more
doaj   +1 more source

Detectors for the James Webb Space Telescope Near-Infrared Spectrograph I: Readout Mode, Noise Model, and Calibration Considerations

open access: yes, 2007
We describe how the James Webb Space Telescope (JWST) Near-Infrared Spectrograph's (NIRSpec's) detectors will be read out, and present a model of how noise scales with the number of multiple non-destructive reads sampling-up-the-ramp.
Augustyn Waczynski   +44 more
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

open access: yesMolecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak   +4 more
wiley   +1 more source

Using Support Vector Machine to Improve Ultrasonic Pulse Velocity Test for Concrete

open access: yesMATEC Web of Conferences, 2018
In the construction industry, to evaluate the compressive strength of concrete, destructive and non-destructive testing methods are used. Non-destructive testing methods are preferable due to the fact that those methods do not destroy concrete samples ...
Loan Ngo Tu Quynh, Wang Yu-Ren
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

A CUSUM test with sliding reference for ground resonance monitoring [PDF]

open access: yes, 2011
Ground resonance is potentially destructive oscillations that may develop on helicopters rotors when the aircraft is on or near the ground. Therefore, this unstable phenomenon has to be detected before it occurs in order to be avoided by the pilot.
Jhinaoui, Ahmed   +2 more
core   +2 more sources

High-Q Nanomechanics via Destructive Interference of Elastic Waves

open access: yes, 2010
Mechanical dissipation poses an ubiquitous challenge to the performance of nanomechanical devices. Here we analyze the support-induced dissipation of high-stress nanomechanical resonators. We develop a model for this loss mechanism and test it on silicon
Barton, R. A.   +6 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

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