Results 51 to 60 of about 139,139 (307)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Sensing of the acoustic signal by waveguides

Acta Universitatis Agriculturae et Silviculturae Mendelianae Brunensis, 2008
The work is focused on the possibilities of accoustic emission (AE) signal sensing from surfaces inaccessible for commonly used sensors. The aim of the work is to verify the possibility of assembly of several measuring devices for maximalization of the ...
Michal Černý, Pavel Mazal, Josef Filípek   +2 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Methodological assessment of the reduction of the content of impurities in nimodipine emulsion via the use of 21 amino acid protection

International Journal of Nanomedicine, 2017
Yiqiao Xie,1,* Zhiquan Zhuang,2,* Shu Zhang,1 Zihua Xia,1 De Chen,1 Kaiyan Fan,1 Jialin Ren,1 CuiCui Lin,1 Yanzhong Chen,1 Fan Yang1 1Department of Pharmaceutics, Guangdong Pharmaceutical University, 2Department of Pharmacy, First Affiliated Hospital of
Xie YQ, Zhuang ZQ, Zhang S, Xia ZH, Chen D, Fan KY, Ren JL, Lin CC, Chen YZ, Yang F   +9 more
doaj  

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

Facing the Dark Side: How Leadership Destroys Organisational Innovation

Journal of Technology Management & Innovation, 2019
Leadership is an essential element for promoting innovation. The literature has primarily focused on the effect of “constructive” leadership on innovation, although numerous studies point out that destructive leadership affects organizational performance.
Paulo Lopes Henriques, Carla Curado, Helena Mateus Jerónimo, Joana Martins   +3 more
doaj   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Application of non destructive testing to the detection of aeronautical defects in composite structures [PDF]

, 2013
A study of two Non-destructive Testing methods (NDT) was carried out in specimens with different kinds of simulated defects. Ultrasonics test (US) and Infrared Thermography (IRT) were applied with the aim to evaluate the detectability and the accuracy of
Munoz Cuartas, Victor, Karama, Moussa, Welemane, Hélène, Welemane, H., Pastor, Marie-Laetitia, Munoz, Victor, Perrin, Marianne, Cantarel, Arthur, Munoz, V., Karama, M.   +9 more
core  

Using Support Vector Machine to Improve Ultrasonic Pulse Velocity Test for Concrete

MATEC Web of Conferences, 2018
In the construction industry, to evaluate the compressive strength of concrete, destructive and non-destructive testing methods are used. Non-destructive testing methods are preferable due to the fact that those methods do not destroy concrete samples ...
Loan Ngo Tu Quynh, Wang Yu-Ren
doaj   +1 more source