Results 101 to 110 of about 1,349,018 (307)

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Development of Detailed Chemistry Models for Boundary Layer Catalytic Recombination [PDF]

, 2015
During the (re-)entry phase of a space vehicle, the gas flow in the shock layer can be in a state of strong thermal non-equilibrium. Under these circumstances, the population of the internal energy levels of the atoms and molecules of the gas deviates ...
Barbante, P. F., Bellas-Chatzigeorgis, G., Magin, T. E.   +2 more
core  

Accurate rate coefficients for models of interstellar gas-grain chemistry

, 2009
The methodology for modeling grain-surface chemistry has been greatly improved by taking into account the grain size and fluctuation effects. However, the reaction rate coefficients currently used in all practical models of gas-grain chemistry are ...
Barzel, Biham, Biham, Biham, Caselli, Chang, Charnley, Cuppen, Garrod, Green, Hasegawa, Herbst, Hollenbach, I. Lohmar, J. Krug, Katz, Krug, Lederhendler, Lipshtat, Lohmar, Lohmar, O. Biham, Stantcheva, Stantcheva, Stantcheva, Tielens   +25 more
core   +1 more source

Direct numerical simulation of non-premixed syngas burning with detailed chemistry

Fuel, 2013
H2/CO syngas non-premixed impinging jet flames were studied using three-dimensional direct numerical simulation (DNS) and flamelet generated manifolds (FGMs) based on detailed chemical kinetics. The computational domain employed has a size of four jet nozzle diameters in the streamwise direction and 12 jet nozzle diameters in the cross-streamwise ...
Ranga Dinesh, K.K.J., Jiang, X., van Oijen, J.A   +2 more
openaire   +5 more sources

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Numerical investigation of reaction kinetics of coal volatiles with a detailed chemistry and its simplification

Journal of Thermal Science and Technology, 2016
Reaction kinetics of coal volatile were numerically investigated based on analyses during reaction mechanism reduction procedure in detail in this paper.
Seongyool AHN, Hiroaki WATANABE, Tetsuya SHOJI, Satoshi UMEMOTO   +3 more
doaj   +1 more source

Observations of Exoplanet Atmospheres

, 2015
Detailed characterization of an extrasolar planet's atmosphere provides the best hope for distinguishing the makeup of its outer layers, and the only hope for understanding the interplay between initial composition, chemistry, dynamics & circulation, and
Crossfield, Ian J. M.
core   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Large Eddy Simulation Of Non-Premixed Combustion With Detailed Chemistry

XXXIX Meeting of the Italian Section of the Combustion Institute, 2016
Poster presented at the XXXIX Meeting of the Italian Section of the Combustion ...
Shamooni, Ali, Cuoci, Alberto, Faravelli, Tiziano   +2 more
openaire   +1 more source