Results 121 to 130 of about 1,349,018 (307)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

ACHIEVEMENTS OF THE INSTITUTE OF CHEMISTRY OF THE ACADEMY OF SCIENCES OF MOLDOVA AT 50 YEARS ANNIVERSARY [PDF]

Chemistry Journal of Moldova: General, Industrial and Ecological Chemistry, 2009
This communication deals with the appearance and development of the research in the field of chemistry in the Republic of Moldova; at the beginning - in chemistry sections of Moldovan Branch of the USSR Academy of Sciences and then - at the Institute of ...
Tudor Lupascu, Pavel F. Vlad, Aculina Aricu, Maria Cocu   +3 more
doaj  

Soft x-rays absorption and high-resolution powder x-ray diffraction study of superconducting CaxLa(1-x)Ba(1.75-x)La(0.25+x)Cu3Oy system

, 2013
We have studied the electronic structure of unoccupied states measured by O K-edge and Cu L-edge x-ray absorption spectroscopy (XAS), combined with crystal structure studied by high resolution powder x-ray diffraction (HRPXRD), of charge-compensated ...
Agrestini, S., Bianconi, A., Concas, G., De Renzi, R., Pusceddu, E., Saini, N. L., Sanna, S., Zheng, K.   +7 more
core   +1 more source

Thematic workshop: spices, the chemistry in small details

, 2020
The present work is an excerpt from a dissertation that defends the use of means of scientific dissemination in a formal teaching context. The research is of a qualitative nature, where a case study was carried out, with the planning of a Thematic Workshop together with graduates in chemistry, members of PIBID, entitled “Spices: Chemistry present in ...
Martins, Joana Laura de Castro, Teixeira, Edileuza Pinto, Babinski, Paola Jennifer, Braibante, Mara Elisa Fortes   +3 more
openaire   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Numerical Study of a Turbulent Burner by Means of RANS and Detailed Chemistry

International Journal of Energetica, 2019
The present paper shows a numerical study of the Co-flow turbulent flame configuration using the Reynolds Averaged Navier-Stokes (RANS) modelling with detailed chemistry.
Mohamed Hafid, Nacer Hebbir, Kamel Bouarour, Senda Trabelsi   +3 more
doaj  

Technical note: A new comprehensive SCAVenging submodel for global atmospheric chemistry modelling

, 2005
International audienceWe present the new scavenging scheme SCAV, simulating the removal of trace gases and aerosol particles by clouds and precipitation in global atmospheric chemistry models.
Jöckel, P., Kerkweg, A., Lelieveld, J., Sander, R., Tost, H.   +4 more
core   +3 more sources

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Screening for lung cancer: A systematic review of overdiagnosis and its implications

Molecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto   +12 more
wiley   +1 more source