Results 71 to 80 of about 43,128 (219)

Illustrative presentation of some basic concepts of network internal reliability with comments as regards engineering surveys

Reports on Geodesy and Geoinformatics, 2016
The paper integrates some earlier and the recent findings of the author in the area of network internal reliability and presents a consistent system of concepts in this respect. The concepts of outlier detection and outlier identification linked directly
Prószyński Witold
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Relative detectability of Canadian plant species at risk in field surveys

Conservation Science and Practice
Accurate species detection is necessary for correct population estimates and species range assessments. Plant species at risk of extinction are particularly under‐studied with respect to detectability. To help improve detection efforts for Canadian plant
Margaret B. Hanna, Ana Hernandez Martinez De La Riva, Audrey C. Gilmour, Joseph R. Bennett   +3 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Prevalence of gastroesophageal reflux disease in moscow: results of a population study

Терапевтический архив, 2008
Aim. To study prevalence of the principal symptoms of gastroesophageal reflux disease (GERD) in Moscow. Material and methods. A total of 1065 respondents aged 15-85 years (a random representative sample of population of one of the typical Moscow ...
L B Lazebnik, Iu V Vasil'ev, A A Masharova, I V Manannikov   +3 more
doaj  

Evaluation of Additive Manufacturing Techniques to Increase Drone Radar Detection Range

Drones
The deployment of drones in civil airspaces has increased rapidly in recent years. However, their small radar cross-section hinders detectability by existing surveillance systems.
Christian Maya, Joaquin Vico Navarro, Juan V. Balbastre Tejedor   +2 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

LINEAR QUADRATIC OPTIMAL CONTROL UNDER STOCHASTIC UNIFORM OBSERVABILITY AND DETECTABILITY CONDITIONS [PDF]

Fiabilitate şi Durabilitate, 2011
In this paper we apply the results in [1] - [3] to solve some linear quadratic control problems undereither stochastic uniform observability conditions or detectability conditions.
V.M. Ungureanu
doaj  

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source