Results 241 to 250 of about 8,661,373 (377)

Loss of proton‐sensing GPR4 reduces tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
G protein‐coupled receptor 4 (GPR4) is a pH‐sensing receptor activated by acidic pH. GPR4 expression is increased in patients with inflammatory bowel disease who are at high risk of developing colorectal cancer. In mouse models, loss of GPR4 attenuated tumor progression. This correlated with increased IL2 and natural killer cell activity.
Leonie Perren, Moana Busch, Pedro A. Ruiz, Ermanno Malagola, Valeria Baumeler, Federica Foti, Adelina Gross, Tobias Grütter, Hendrik Edel, Cordelia Schuler, Kristina Handler, Glenn De Lange, Isabelle C. Arnold, Cheryl de Vallière, Klaus Seuwen, Martin Hausmann, Gerhard Rogler   +16 more
wiley   +1 more source

Highly stable bismuth-chloride perovskite X-ray direct detectors with an ultralow detection limit. [PDF]

Chem Sci
Chen H, Han Q, Qin H, Shen Y, Lv H, Liu Y, Du L, Wang Y, He Y, Ning W.   +9 more
europepmc   +1 more source

Role of graphene quantum dots with discrete band gaps on SnO₂ nanodomes for NO₂ gas sensors with an ultralow detection limit. [PDF]

Nanoscale Adv, 2023
Lee J, Park M, Song YG, Cho D, Lee K, Shim YS, Jeon S.   +6 more
europepmc   +1 more source

TRPM8 levels determine tumor vulnerability to channel agonists

Molecular Oncology, EarlyView.
TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo, Francesco Giuseppe Carbone, Kristi Buzo, Nicole Annesi, Sacha Genovesi, Annalisa Lorenzato, Karen Widmann, Michela Libergoli, Elisa Marmocchi, Giovanni Bertalot, Alberto Brolese, Mauro Giulio Papotti, Luca Molinaro, Orazio Caffo, Mattia Barbareschi, Alberto Bardelli, Alessandro Romanel, Sabrina Arena, Andrea Lunardi   +18 more
wiley   +1 more source

Instantaneous self-recovery and ultra-low detection limit hydrogel electronic sensor for temporomandibular disorders intelligent diagnosis. [PDF]

Nat Commun
Yan Y, Yu L, Zhang X, Han Q, Yang Z, Lu X, Wang J, Xu H, Chen Q, Zhao H.   +9 more
europepmc   +1 more source

The anticancer effect of the HDAC inhibitor belinostat is enhanced by inhibitors of Bcl‐xL or Mcl‐1 in ovarian cancer

Molecular Oncology, EarlyView.
The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine, Sterenn Guillemot, Louis‐Bastien Weiswald, Romane Florent, Edwige Abeilard, Florence Giffard, Emilie Brotin, Mélanie Briand, Enora Dolivet, Laurent Poulain, Marie Villedieu   +10 more
wiley   +1 more source

Single high-sensitivity troponin-I for ruling out acute coronary syndrome: a detection limit approach. [PDF]

Eur Heart J Open
Hickling S, Francis CJ, Chew DP, Mitra B, Hillis GS.   +4 more
europepmc   +1 more source

Imputation of Below Detection Limit Missing Data in Chemical Mixture Analysis with Bayesian Group Index Regression. [PDF]

Int J Environ Res Public Health, 2022
Carli M, Ward MH, Metayer C, Wheeler DC.
europepmc   +1 more source

Synthesis, Spectral Properties, and Detection Limits of Reactive Squaraine Dyes, a New Class of Diode Laser Compatible Fluorescent Protein Labels

, 2000
B. Oswald, L. D. Patsenker, Josef Duschl, Henryk Szmacinski, Otto S. Wolfbeis, Ewald Terpetschnig   +5 more
openalex   +1 more source

X‐Ray Bursts in Neutron Star and Black Hole Binaries from Unconventional Stellar Aspect Experiment andRossi X‐Ray Timing ExplorerData: Detections and Upper Limits [PDF]

, 2003
D. Tournear, E. Raffauf, E. D. Bloom, W. B. Focke, B. Giebels, G. Godfrey, P. M. Saz Parkinson, K. T. Reilly, K. S. Wood, Paul S. Ray, M. T. Wolff, R. M. Bandyopadhyay, M. N. Lovellette, Jeffrey D. Scargle   +13 more
openalex   +1 more source