IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo
FEBS Open Bio, EarlyView.To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
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Survey methodology for detecting eastern massasauga rattlesnakes in southern Michigan
Wildlife Society Bulletin, 2019 The U.S. Fish and Wildlife Service listed the eastern massasauga rattlesnake (Sistrurus catenatus catenatus) as threatened in 2016 under the 1973 Endangered Species Act.
Stephanie A. Shaffer +2 more
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Observation of Nociceptive Processing: Effect of Intra-Epidermal Electric Stimulus Properties on Detection Probability and Evoked Potentials. [PDF]
Brain Topogr, 2021 van den Berg B, Buitenweg JR.
europepmc +1 more source
Aging and Cancer, EarlyView.This prospective study demonstrates that laparoscopic sphincter‐preserving surgery is feasible for elderly patients. While overall survival reaches 70% at 5 years, advanced T‐stage and the omission of neoadjuvant therapy significantly drive recurrence, highlighting the need for personalized geriatric protocols despite logistical challenges.
Huu Duc Ho +4 more
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Life history traits influence method-specific detection of native and invasive amphibians
Frontiers in Amphibian and Reptile ScienceIntroductionEfficient and effective monitoring is essential for informing conservation efforts and determining where to focus management actions. Newly arriving invasive and declining native taxa are often the focus of conservation programs, but these ...
Waverly Davis +2 more
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Interference Suppression Performance of Automotive UWB Radars Using Pseudo Random Sequences [PDF]
Radioengineering, 2015 Ultra wideband (UWB) automotive radars have attracted attention from the viewpoint of reducing traffic accidents. The performance of automotive radars may be degraded by interference from nearby radars using the same frequency.
I. Pasya, H. Kato, T. Kobayashi
doaj
Estimating ungulate abundance while accounting for multiple sources of observation error
Wildlife Society Bulletin, 2016 Whether a species is rare or overabundant, accurate estimates of population abundance are essential for the development and assessment of conservation plans and management goals.
Pat A. Terletzky, David N. Koons
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Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
Aging and Cancer, EarlyView.This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
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The importance of simulation assumptions when evaluating detectability in population models
Ecosphere, 2019 Population monitoring is important for investigating a variety of ecological questions, and N‐mixture models are increasingly used to model population size (N) and trends (λ) while estimating detectability (p) from repeated counts within primary periods (
Adrian P. Monroe +3 more
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Predictive Ability of Plasma p‐tau217 for β‐Amyloid Status: A Prospective Multicenter Study
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Plasma tau phosphorylated at threonine 217 (p‐tau217) measured with fully automated platforms has shown high accuracy for Alzheimer's disease (AD) diagnosis, but real‐world multicenter data remain limited. We aimed to validate the diagnostic performance of p‐tau217 for identifying AD pathology in a real‐world multicenter cohort ...
Miquel Massons +33 more
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