Results 101 to 110 of about 1,699,991 (339)

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

open access: yesFEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes   +32 more
wiley   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

open access: yesFEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman   +4 more
wiley   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

open access: yesFEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Accounting for detection probability with overestimation by integrating double monitoring programs over 40 years. [PDF]

open access: yesPLoS One, 2022
Vallecillo D   +8 more
europepmc   +1 more source

On the probability of undetected error for the maximum distance separable codes [PDF]

open access: yes
The performance of maximum-distance-separable codes with symbols from GF(1) when they are used for pure error detection or for simultaneous error correction and detection is investigated. These codes are good for symbol error detection. Their probability
Kasami, T., Lin, S.
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

Patterns of Monarch Site Occupancy and Dynamics in Iowa

open access: yesFrontiers in Ecology and Evolution, 2019
The monarch butterfly (Danaus plexippus) is the focus of large-scale habitat restoration efforts because of recent population declines. From 2006-2017 we monitored monarchs at >400 sites throughout Iowa to link site occupancy and colonization ...
Stephen J. Dinsmore   +4 more
doaj   +1 more source

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