Results 141 to 150 of about 1,700,049 (319)
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Pneumococcal Pneumonia and Invasive Pneumococcal Disease in Those 65 and Older: Rates of Detection, Risk Factors, Vaccine Effectiveness, Hospitalisation and Mortality. [PDF]
Geriatrics (Basel), 2021 Thomas RE.
europepmc +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Global Disease Detection : detecting and containing health threats [PDF]
GDD operates as CDC\u2019s platform for developing and strengthening global capacity to rapidly detect, accurately identify, and promptly contain emerging infectious disease and bioterrorist threats that occur internationally.Enhancing global health ...
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Background: Dental caries is a multifactorial pathological condition and highly prevalent non-communicable disease, particularly in children, with significant impacts on health and quality of life.
Dapala, Zelka +4 more
core +1 more source
Leak detection using instantaneous frequency analysis [PDF]
, 2012 Leaking pipes are a primary concern for water utilities around the globe as they compose a major portion of losses. Contemporary interest surrounding leaks is well documented and there is a proliferation of leak detection techniques. Although the reasons
M. F., Ghazali, ghazali, mohd fairusham
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Enhanced Leak Detection Risk Model Development
, 2010 Increasing concerns and attention to pipeline safety have engaged pipeline companies and regulatory agencies to extend their approaches to pipeline integrity.
Ted Farquhar, Lorna Harron, Rick Barlow
core +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Early detection and management of the high-risk patient with elevated blood pressure
, 2008 Cristina Sierra, Alejandro de la SierraHypertension Unit, Department of Internal Medicine, Hospital Clinic. University of Barcelona, SpainAbstract: Severe or important blood pressure elevations are associated with the risk of cardiovascular disease ...
Cristina Sierra, Alejandro de la Sierra
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Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source