Metabolism Profile of Mequindox in Sea Cucumbers in Vivo Using LC-HRMS [PDF]
Antibiotics, 2022 In this work, the metabolism behavior of mequindox (MEQ) in sea cucumber in vivo was investigated using LC-HRMS. In total, nine metabolites were detected and identified as well as the precursor in sea cucumber tissues.
Yongning Wu, Yanshen Li, Xin Mao
exaly +7 more sources
UPLC-MS/MS Method for Simultaneous Determination of Three Major Metabolites of Mequindox in Holothurian [PDF]
Journal of Analytical Methods in Chemistry, 2018 This study developed an ultraperformance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) method for the detection of three major metabolites of mequindox, including 3-methyl-quinoxaline-2-carboxylic acid, 1-desoxymequindox, and 1,4 ...
Huihui Liu +9 more
doaj +7 more sources
Mequindox Induced Genotoxicity and Carcinogenicity in Mice [PDF]
Frontiers in Pharmacology, 2018 Mequindox (MEQ), acting as an inhibitor of deoxyribonucleic acid (DNA) synthesis, is a synthetic heterocyclic N-oxides. To investigate the potential carcinogenicity of MEQ, four groups of Kun-Ming (KM) mice (50 mice/sex/group) were fed with diets ...
Qianying Liu +14 more
doaj +7 more sources
Mechanisms of the Testis Toxicity Induced by Chronic Exposure to Mequindox [PDF]
Frontiers in Pharmacology, 2017 Mequindox (MEQ) is a synthetic antimicrobial agent widely used in China since the 1980s. Although the toxicity of MEQ is well recognized, its testis toxicity has not been adequately investigated.
Qianying Liu +9 more
doaj +8 more sources
The Reproductive Toxicity of Mequindox in a Two-Generation Study in Wistar Rats [PDF]
Frontiers in Pharmacology, 2018 Mequindox (MEQ), belonging to quinoxaline-di-N-oxides (QdNOs), has been extensively used as a synthetic antibacterial agent. To evaluate the reproductive toxicity of MEQ, different concentrations of MEQ were administered to Wistar rats by feeding diets ...
Qianying Liu +12 more
doaj +6 more sources
Mequindox-Induced Kidney Toxicity Is Associated With Oxidative Stress and Apoptosis in the Mouse [PDF]
Frontiers in Pharmacology, 2018 Mequindox (MEQ), belonging to quinoxaline-di-N-oxides (QdNOs), is a synthetic antimicrobial agent widely used in China. Previous studies found that the kidney was one of the main toxic target organs of the QdNOs.
Qianying Liu +16 more
doaj +7 more sources
Natural occurrences and characterization of Elizabethkingia miricola infection in cultured bullfrogs (Rana catesbeiana) [PDF]
Frontiers in Cellular and Infection Microbiology, 2023 IntroductionThe bacterium Elizabethkingia miricola is a multispecies pathogen associated with meningitis-like disease that has been isolated from several amphibian species, including the bullfrog, but this is the first isolation in Guangxi.
Dongdong Wei +14 more
doaj +4 more sources
Corrigendum: The Reproductive Toxicity of Mequindox in a Two-Generation Study in Wistar Rats [PDF]
Frontiers in Pharmacology, 2018 [This corrects the article DOI: 10.3389/fphar.2018.00870.].
Qianying Liu +12 more
doaj +5 more sources
Comparison of Antimicrobial Resistance, Virulence Genes, Phylogroups, and Biofilm Formation of Escherichia coli Isolated From Intensive Farming and Free-Range Sheep [PDF]
Frontiers in Microbiology, 2021 Pathogenic E. coli are among the most frequently isolated bacterial pathogens on large-scale sheep farms in China. Antibiotic use in wool sheep production is a risk factor for promoting the emergence of resistant E. coli.
Xueliang Zhao +12 more
doaj +2 more sources
Action Mechanism of Essential Oils or Their Components Against Pathogenic Bacteria: Literature Review [PDF]
International Journal of Microbiology, Volume 2026, Issue 1, 2026.Essential oils (EOs), derived from medicinal and aromatic plants, are natural mixtures of volatile, oily compounds with varying compositions and antibacterial mechanisms. Understanding the mechanisms of EOs and their components (EOCs) is essential for predicting their impacts on various microbes and their interactions with antibiotics.
Mohamed A. El-Sakhawy +9 more
wiley +2 more sources