Results 21 to 30 of about 232 (109)

Spectroscopic Studies on the Binding of Bacteriophage Mequindox with Bovine Serum Albumin

Chinese Journal of Chemistry, 2009
AbstractFluorescence spectra and UV‐Vis absorption spectra have been used to study the binding of bacteriophage mequindox (MEQ) with bovine serum albumin (BSA), which performed a dynamic quenching process. The quenching constants and thermodynamic parameters at different temperatures were calculated.
Zhouhua ZENG, Yi LIU, Xianming HU, Zhenqiang XU, Kun ZENG   +4 more
openaire   +2 more sources

Long-term mequindox treatment induced endocrine and reproductive toxicity via oxidative stress in male Wistar rats

Toxicology and Applied Pharmacology, 2011
Mequindox (MEQ) is a synthetic antimicrobial chemical of quinoxaline 1, 4-dioxide group. This study was designed to investigate the hypothesis that MEQ exerts testicular toxicity by causing oxidative stress and steroidal gene expression profiles and determine mechanism of MEQ testicular toxicity.
Awais, Ihsan, Xu, Wang, Zhaoying, Liu, Yulian, Wang, Xianju, Huang, Yu, Liu, Huan, Yu, Hongfei, Zhang, Tingting, Li, Chunhui, Yang, Zonghui, Yuan   +10 more
openaire   +3 more sources

Metabolites and JAK/STAT pathway were involved in the liver and spleen damage in male Wistar rats fed with mequindox

Toxicology, 2011
Mequindox (MEQ) is a novel synthetic quinoxaline 1,4-dioxides antibacterial agent and growth promoter in animal husbandry. This study was to investigate whether reactive oxygen species (ROS), the Janus kinase-signal transducer and activator of transcription (JAK/STAT) pathway, suppressors of cytokine signaling (SOCS) and inflammatory cytokines were ...
Xu, Wang, Xian-Ju, Huang, Awais, Ihsan, Zhao-Ying, Liu, Ling-Li, Huang, Hua-Hai, Zhang, Hong-Fei, Zhang, Wen, Zhou, Qin, Liu, Xi-Juan, Xue, Zong-Hui, Yuan   +10 more
openaire   +3 more sources

The structure elucidation of mequindox and 1,4-bisdesoxymequindox: NMR analyses, FT-IR spectra, DFT calculations and thermochemical studies

Journal of Molecular Structure, 2011
In the current work, we report a combined experimental and theoretical study on the molecular conformation, vibrational spectra, and nuclear magnetic resonance (NMR) spectra of mequindox (MEQ) and 1,4-bisdesoxymequindox (1,4-BDM). The geometric structure and vibrational frequencies of MEQ and 1,4-BDM have been calculated by density functional theory ...
Jiaheng Zhang, Xin He, Haixiang Gao
openaire   +2 more sources

Interactions of NADPH oxidase, renin–angiotensin–aldosterone system and reactive oxygen species in mequindox-mediated aldosterone secretion in Wistar rats

Toxicology Letters, 2010
High doses of mequindox (MEQ) are associated with oxidative stress and pathological toxicity in the kidney. In this study, we demonstrated long term effects of MEQ on intra- or extra-adrenal renin-angiotensin-aldosterone system (RAAS) in vivo. RAAS plays a major role in aldosterone secretion.
Xian-Ju, Huang, Xu, Wang, Awais, Ihsan, Qin, Liu, Xi-Juan, Xue, Shi-Jia, Su, Chun-Hui, Yang, Wen, Zhou, Zong-Hui, Yuan   +8 more
openaire   +3 more sources

Olaquindox‐Induced Liver Damage Involved the Crosstalk of Oxidative Stress and p53 In Vivo and In Vitro

Oxidative Medicine and Cellular Longevity, Volume 2020, Issue 1, 2020., 2020
Olaquindox (OLA), a member of the quinoxaline‐N,N‐dioxide family, has been widely used as a growth‐promoting feed additive and treatment for bacterial infections. The toxicity has been a major concern, and the precise molecular mechanism remains poorly understood. The present study was aimed at investigating the roles of oxidative stress and p53 in OLA‐
Daowen Li, Xingyao Pei, Xiaoling Qin, Xinyu Liu, Cun Li, Liuan Li, Chongshan Dai, Xilong Xiao, Shusheng Tang, Alexandros Georgakilas   +9 more
wiley   +1 more source

Systems Responses of Rats to Mequindox Revealed by Metabolic and Transcriptomic Profiling

, 2016
Mequindox is used as an antibiotic drug in livestock; however, its toxicity remains largely unclear. Previously, we investigated metabolic responses of mice to mequindox exposure.
Xiu-Ju Zhao (2047783), Fuhua Hao (465714), Hehua Lei (1609093), Mattias Rantalainen (166786), Chongyang Huang (1429291), Huiru Tang (115310), Yulan Wang (50197)   +6 more
core   +2 more sources

Toxic metabolites, MAPK and Nrf2/Keap1 signaling pathways involved in oxidative toxicity in mice liver after chronic exposure to Mequindox. [PDF]

Sci Rep, 2017
AbstractMequindox (MEQ) is a synthetic antimicrobial agent of quinoxaline-1,4-dioxide group (QdNOs). The liver is regarded as the toxicity target of QdNOs, and the role of N → O group-associated various toxicities mediated by QdNOs is well recognized. However, the mechanism underlying the in vivo effects of MEQ on the liver, and whether the metabolic ...
Liu Q, Lei Z, Huang A, Wu Q, Xie S, Awais I, Dai M, Wang X, Yuan Z.   +8 more
europepmc   +4 more sources

A Milk Extracellular Vesicle‐Based Nanoplatform Enhances Combination Therapy Against Multidrug‐Resistant Bacterial Infections

Advanced Science, Volume 12, Issue 7, February 17, 2025.
Treating multidrug‐resistant bacteria with a single antibiotic is becoming increasingly difficult, leading to a gradual rise in global infections and deaths. Here, a bio‐inspired delivery system equipped with combination therapy and paracellular transport has been proven to deliver and slowly release a combination of drugs through oral administration ...
Shaoqi Qu, Shuo Yang, Qingjun Xu, Mengying Zhang, Feng Gao, Yongning Wu, Lin Li   +6 more
wiley   +1 more source

Dynamic Metabolic Response of Mice to Acute Mequindox Exposure

, 2016
Mequindox is used as a veterinary antibiotic drug. As part of systematic investigations into mequindox as a veterinary medicine and its subsequent applications in food safety, we conducted the investigation to assess the metabolic response of mice to ...
Xiu-Ju Zhao (2047783), Hehua Lei (1609093), Chongyang Huang (1429291), Huiru Tang (115310), Xiu Nie (110611), Yulan Wang (50197)   +5 more
core   +1 more source