Corrigendum: Mequindox Induced Genotoxicity and Carcinogenicity in Mice [PDF]
Frontiers in Pharmacology, 2018 [This corrects the article DOI: 10.3389/fphar.2018.00361.].
Qianying Liu +14 more
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Determination of Residues of two Aminoglycoside antibiotics and five Quinololine antibiotics and Their Metabolites in Penaeus vannamei by Ultra High Performance Liquid Chromatography Tandem Mass Spectrometry [PDF]
E3S Web of Conferences, 2020 An ultra performance liquid chromatography – electrospray ionization triple-quadruple tandem mass spectrometric(UPLC–ESI MS /MS) method was developed for determining Quinololine antibiotics (Carbadox,, Quinocetone, Mequindox, Olaquindox, Cyadox ...
Zha Yu-bing +9 more
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Effects of
BMC Veterinary Research, 2012 Background Lactobacillus plantarum is a plant-associated bacterial species but it has also been found in human, mouse and porcine gastrointestinal tracts.
Suo Cheng +6 more
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Metabolism of Mequindox in Isolated Rat Liver Cells
Journal of Integrative Agriculture, 2014 Mequindox (MEQ), 3-methyl-2-quinoxalinacetyl-1,4-dioxide, is widely used in Chinese veterinary medicine as an antimicrobial agent and feed additive. Its toxicity has been reported to be closely related to its metabolism.
Guang-hui LI +5 more
doaj +2 more sources
Preparation of mequindox microemulsion and its transdermal permeability in vitro
浙江大学学报. 农业与生命科学版, 2012 Aiming to develop the transdermal formulation of mequindox microemulsion (M-ME) and evaluate its stability and the transdermal permeability in vitro skin, the best prescription was optimized through the pseudoternary phase diagrams, and the M-ME was ...
WU Jing-chao +5 more
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Pharmacokinetics of mequindox after intravenous and intramuscular administration to goat [PDF]
, 2016 Pharmacokinetics and bioavailability of mequindox were determined after single intravenous (i.v.) or intramuscular (i.m.) administrations of 7 mg/kg body weight (b.w.) to 10 healthy adult goats. Plasma mequindox concentrations were measured by high performance liquid chromatography.
Li, Yinqian +4 more
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Physiologically based pharmacokinetic model for quinocetone in pigs and extrapolation to mequindox
Food Additives & Contaminants: Part A, 2016 Physiologically based pharmacokinetic (PBPK) models are scientific methods used to predict veterinary drug residues that may occur in food-producing animals, and which have powerful extrapolation ability. Quinocetone (QCT) and mequindox (MEQ) are widely used in China for the prevention of bacterial infections and promoting animal growth, but their ...
Xudong, Zhu +7 more
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Journal of Chromatographic Science, 2022 AbstractThis research proposed and validated an LC-MSMS method for five reduction and hydroxylation metabolites of Mequindox (MEQ) as well as the precursor in holothurian samples. Specially, three hydroxylation metabolites (2-isoethanol-mequindox, M3, 2-isoethanol-1-desoxymequindox, M4 and 2-isoethanol-4-desoxymequindox, M5) are novel for analysis ...
Yonggang Li +8 more
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Metabolism, Distribution, and Elimination of Mequindox in Pigs, Chickens, and Rats
Journal of Agricultural and Food Chemistry, 2015 Mequindox (MEQ), a quinoxaline-N,N-dioxide antibacterial agent used to control bacterial enteritis in various food-producing animals, is a potential violative residue in food animal-derived products. The disposition and elimination of MEQ in rats, pigs, and chickens was comprehensively investigated to identify the marker residue and target tissue of ...
Lingli, Huang +7 more
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Toxic metabolites, Sertoli cells and Y chromosome related genes are potentially linked to the reproductive toxicity induced by mequindox. [PDF]
Oncotarget, 2017 Mequindox (MEQ) is a relatively new synthetic antibacterial agent widely applied in China since the 1980s. However, its reproductive toxicity has not been adequately performed. In the present study, four groups of male Kunming mice (10 mice/group) were fed diets containing MEQ (0, 25, 55 and 110 mg/kg in the diet) for up to 18 months.
Liu Q, Lei Z, Dai M, Wang X, Yuan Z.
europepmc +5 more sources