Results 181 to 190 of about 2,823,042 (391)

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Itinerant Microwave Photon Detector [PDF]

, 2018
Baptiste Royer, Arne L. Grimsmo, Alexandre Choquette-Poitevin, Alexandre Blais   +3 more
openalex   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Probabilistic vortex crossing criterion for superconducting nanowire single-photon detectors [PDF]

, 2020
Saman Jahani, Li‐Ping Yang, Adrián Buganza Tepole, Joseph C. Bardin, Hong X. Tang, Zubin Jacob   +5 more
openalex   +1 more source

Improving the dynamic range of single photon counting kinetic inductance detectors [PDF]

, 2021
Nicholas Zobrist, Nikita Klimovich, Byeong Ho Eom, G. Coiffard, M. Daal, Noah Swimmer, Sarah Steiger, B. Bumble, H. G. LeDuc, Peter K. Day, Benjamin A. Mazin   +10 more
openalex   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Response simulation and primary vertex reconstruction in the SPD NICA straw tracker

Вестник Самарского университета: Естественнонаучная серия
In this work we investigate the temporal structure of the events in the spin physics detector (SPD) straw tracker at the JINR NICA. Using the Geant4 toolkit we simulate the response of the straw layers sensitive elements in the triggerfree regime of SPD.
S. D. Morozova, A. V. Shipilova
doaj   +1 more source

CATM-CFAR detector in the receiver of the software defined radar [PDF]

Scientific Technical Review, 2014
This paper presents a model of the CATM-CFAR detector in the receiver of the software defined radar. The mentioned detector is named cell-averaging-trimmed-mean CFAR. It is a combination of cell-averaging and trimmed mean CFAR.
Ivković Dejan, Andrić Milenko, Zrnić Bojan, Okiljević Predrag, Kozić Nadica   +4 more
doaj  

Zero-point excitation of a circularly moving detector in an atomic condensate and phonon laser dynamical instabilities [PDF]

, 2020
Jamir Marino, Gabriel Menezes, Iacopo Carusotto   +2 more
openalex   +1 more source