Results 111 to 120 of about 6,329,140 (296)
The FASER detector: from concept to operation
, 2022 FASER is a new experiment placed 480 meters downstream of the ATLAS interaction point at the LHC. FASER is designed to discover light and very weakly-interacting particles such as dark photons that are produced in the far-forward region of the LHC ...
Otono, Hidetoshi
core
‘Guide and Prejudice’— How Argonautes recognize targets across domains of life
FEBS Letters, EarlyView.Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
, 1980 Prototype of UA1 central detector inside a plexi tube. The UA1 experiment ran at CERN's Super Proton Synchrotron and made the Nobel Prize winning discovery of W and Z particles in 1983.
core
Development of prototype components for the Silicon Tracking System of the CBM experiment at FAIR [PDF]
, 2013 Das CBM-Experiment an der zukuenftigen Beschleunigeranlage FAIR wird die Eigenschaften von Kernmaterie unter extremen Bedingungen untersuchen. Das experimentelle Programm unterscheidet sich von den Schwerionen-Experimenten an RHIC (BNL) und LHC (CERN ...
Lymanets, Anton (Dr.), Lymanets, Anton
core
The Stable Oscillatory Regime in a Neuron Net Consisting of Generalized Automatic Neuron-detectors
Моделирование и анализ информационных систем, 2007 A new model of the neuron cell - the generalized automatic neuron (GAN) - is considered. This model has a universal character. It combines the properties of neuron-oscillator and neuron-detector. The neuron net is formed on the base of this GAN-detector.
E.V. A Konovalov
doaj
Top-quark properties and mass measurements with the ATLAS detector
EPJ Web of Conferences, 2018 The top quark is unique among the known quarks in that it decays before it has an opportunity to form hadronic bound states. This makes measurements of its properties particularly interesting as one can access directly the properties of a bare quark. The
Dado Tomas
doaj +1 more source
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source