Results 111 to 120 of about 378,573 (266)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Editorial: Silicon radiation detectors: Status and perspectives

Frontiers in Physics, 2022
Marco Carminati, Marco Carminati, Gabriele Giacomini, Jelena Ninkovic   +3 more
doaj   +1 more source

Measurement of Percentage Depth–Dose Distributions in Clinical Dosimetry: Conventional Techniques and Emerging Sensor Technologies

Sensors
Percentage depth–dose (PDD) distributions are fundamental to characterizing radiation beams in radiotherapy. This review provides an overview of both methods and sensor technologies for measuring PDD in photon, electron, proton, and carbon-ion beams.
Giada Petringa, Luigi Raffaele, Giacomo Cuttone, Mariacristina Guarrera, Alma Kurmanova, Roberto Catalano, Giuseppe Antonio Pablo Cirrone   +6 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Study of gas Cherenkov detectors for high momentum charged particle identification

, 2007
We present here an exhaustive study of the possibilities offered by a combination of a gas radiator of the highest index of refraction commercially available (C5F12) with the proven concept of large area CsI photocathodes instrumenting either a multiwire
Martinengo P., Di Mauro, A., Nappi E., Martinengo, P, Volpe G., Paic, G, DI BARI, Domenico, VOLPE, GIACOMO, Martinengo, P., Paic, G., García, E, Nappi, E, Di Bari, D, Di Mauro, A, Di Mauro A., Garcia E., Paic G., Garcia, E., Nappi, E., Di Bari, D., Volpe, G, Shileev, K A, Shileev, K. A., Shileev K. A.   +23 more
core   +1 more source

A deep learning framework for automated fracture detection and localization in radiographic images using convolutional neural networks

Frontiers in Medicine
BackgroundFracture detecting and localizing in radiographic images is essential to enhance the effectiveness of the diagnosis of trauma and allow the image to be interpreted. Despite the potential potential of the deep learning in musculoskeletal imaging,
Jiangdong Lu, Jie Ding, Penglong Wang, Boyan Mi, Panyu Zhou, Feng Zheng   +5 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

The effect of radiation on ion-implanted silicon detectors

, 1985
Investigations on changes of characteristics of ion-implanted Si-junction detectors when exposed to various does of radiation (106 rad) were performed. The increase of leakage current depends not only on the dose but also on the gradient of irradn. For
Groppi, F, Seidman, A, Campanella, M, M. Campanella, F. Lemeilleur, F. Groppi, N. Croitoru, Lemeilleur, F, S. Pensotti, Pensotti, S, A. Seidman, Rancoita, P G, P. G. Rancoita, Croitoru, N   +13 more
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source