Results 81 to 90 of about 93,770 (286)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Capillary detectors

, 1998
The option for a microvertex detector using glass capillary arrays filled with liquid scintillator is presented. The status of capillary layers development and possible read-out techniques for high rate environment are reported. (C) 1998 Elsevier Science
P. Koppenburg, I. Kreslo, Govorun, V N, A. Ereditato, Vasilchenko, V G, Goldberg, J, Winter, Klaus, V. Vasil'Chenko, E. Kozarenko, G. Martellotti, V. Vasil’chenko, Höpfner, K, S. Buontempo, Liberti, B, S. Golovkin, B. Liberti, Golovkin, S V, J. Goldberg, J. P. Fabre, T. Wolff, A. Ekimov, Fabre, Jean-Paul, V. Govorun, Wilquet, G, Frenkel, A, Buontempo, S, PENSO, Gianni, Bay, A, Currat, C, Frekers, D, G. Wilquet, K. Hoepfner, K. Winter, J.P. Fabre, C. Currat, A. Frenkel, Koppenburg, P, Wolff, T, Kreslo, I E, A. Medvedkov, Ekimov, A V, Konijn, J, Martellotti, G, Medvedkov, A M, A. Bay, Penso, G, J. Konijn, D. Frekers, Ereditato, A, P. Vilain, Vilain, P, G. Penso, Kozarenko, E N   +52 more
core   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Periodontitis bone loss detection in panoramic radiographs using modified YOLOv7 [PDF]

PeerJ Computer Science
Periodontitis is a common dental disease that results in tooth loss, if not diagnosed and treated in time. However, diagnosing bone loss due to periodontitis from panoramic radiographs is a time-consuming and error-prone process, requiring extensive ...
Mohammed Gamal Ragab, Said Jadid Abdulkadir, Nadhem Qaid, Taimoor Muzaffar Gondal, Alawi Alqushaibi, Rizwan Qureshi, Furqan Shaukat   +6 more
doaj   +2 more sources

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Reconstruction of Neutron Spectra Using Silicon Carbide Detectors in Monoenergetic Fields with Machine Learning Approach [PDF]

EPJ Web of Conferences
Recent advancements in machine learning have shown significant promise in nuclear applications, particularly in optimizing reactor operations, core design, and improving neutron spectroscopy techniques.
Belfiore Enrica, Chalil Achment, Ben Mosbah Mehdi, Antoni Rodolphe, Llido Olivier, Lyoussi Abdallah, Destouches Christophe, Slavicek Tomas, Šagátová Andrea, Groetz Jean-Emmanuel   +9 more
doaj   +1 more source

Using a dynamically selective support vector data description model to discover novelties in the control system of electric arc furnace

Measurement + Control, 2020
As increasing data-driven control strategies are applied in electric arc furnace systems, the problem of novelty detection has drawn more attentions than before.
Jiong Zhang, Yue Wang, Qian Li, Biao Wang   +3 more
doaj   +1 more source

Signal processing for radiation detectors

, 2017
This book provides a clear understanding of the principles of signal processing of radiation detectors. It puts great emphasis on the characteristics of pulses from various types of detectors and offers a full overview on the basic concepts required to ...
Nakhostin, Mohammad, Mohammad Nakhostin
core   +1 more source