Results 201 to 210 of about 214,333 (261)

Hyperactive KIF5A in Neurodegeneration

open access: yesCytoskeleton, EarlyView.
ABSTRACT The highly polarised morphology of neurons and the sheer length of their axons make transport of cargoes throughout the cell a formidable task. Decades of evidence obtained from genetic studies on patients and animal models highlight deficits in axonal transport as a recurrent cause, or early contributing factor, in a plethora of ...
David Villarroel‐Campos   +1 more
wiley   +1 more source

Empirical PK/PD Model for Differentiating Intrinsic Dosing Rules by Therapeutic Indication With Relevance for HIV‐1 Latency Reversal

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Romidepsin (RMD), an FDA‐approved histone deacetylase inhibitor for treating cancer, demonstrates potent latency‐reversing activity in vitro but has yielded suboptimal outcomes in kick‐and‐kill HIV‐cure trials when administered as a 5 mg/m2 infusion.
Lauren A. R. Tompkins   +7 more
wiley   +1 more source

Perceived importance and didactic difficulty of chemistry education: Insights from Czech teachers

open access: yesThe Curriculum Journal, EarlyView.
Abstract This empirical study examines how chemistry teachers in lower and upper secondary schools in the Czech Republic evaluate the content of the chemistry curriculum, focussing on its perceived importance and didactic difficulty. Based on a quantitative survey (N = 146), the study provides insight into the pedagogical content knowledge of ...
Jitka Lorenzová   +6 more
wiley   +1 more source

Membrane lipid metabolism as a regulatory frontier in neural crest biology: Roles for sphingolipids, cholesterol, and lipid rafts

open access: yesDevelopmental Dynamics, EarlyView.
Abstract Neural crest cells are multipotent, migratory stem‐like cells essential for vertebrate development that contribute broadly to many tissues including the craniofacial skeleton, peripheral nervous system, and pigment‐producing cells. Their development progresses through phases of induction, specification, delamination, migration, and ...
Allison E. Mancini   +2 more
wiley   +1 more source

Effects of dried distillers' grains inclusion on performance, feed efficiency, carcass traits and health of feedlot lambs. [PDF]

open access: yesTrop Anim Health Prod
Ferreira J   +5 more
europepmc   +1 more source

Directly Sunlight‐Chargeable Core‐Shell Azobenzene Fabric via Coaxial Electrospinning with Tunable Personal Thermal Management

open access: yesENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
This work presents a leakage‐free, sunlight‐chargeable core‐shell Azo‐based textile that effectively bridges molecular photothermal storage with wearable functionality, offering a robust platform for on‐demand solar‐powered personal thermal management.
Yating Zhang   +6 more
wiley   +1 more source

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