Results 151 to 160 of about 1,223,119 (315)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Association between packed red blood cell transfusion and clinical deterioration in neonatal necrotizing enterocolitis: a systematic review and meta-analysis. [PDF]

Ann Med
Huang J, Gao Q, Xu Z, Wang H.
europepmc   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Endogenous Recovery of Fasting C-Peptide Decreases Progression of Sudomotor Small-Fibre Dysfunction in Adults With Diabetes: A Real-World Cohort Study. [PDF]

Diabetes Metab Res Rev
Cai Q, Xie T, Gong H, Zhang W, Guo L, Pan Q.   +5 more
europepmc   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

The therapeutic opportunities and pitfalls of using iron ion chelators to treat neurodegenerative diseases

FEBS Letters, EarlyView.
Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley   +1 more source

Systemic Inflammation Response Index Predicts Thrombolytic Therapy Requirement in Intermediate-High Risk Acute Pulmonary Embolism: A Retrospective Study. [PDF]

J Clin Med
Çiçek T, Yeşildağ K.
europepmc   +1 more source

Deterioration and Conservation [PDF]

, 2018
High, Kirsty Elizabeth, Penkman, Kirsty Elizabeth Helena, Milner, Nicola, Boreham, S., Boreham, J., Needham, Andy, Panter, Ian, Felter, Magrethe, Knight, Becky, Elliott, Ben, Bamforth, Mike, Taylor, Maisie, Rowley, Charlotte Catherine Aneliese   +12 more
openaire   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

An integration of bacterial probiotic extract and green nanoparticles as a safe approach for conservation of historical manuscript against fungal deterioration: an applied study. [PDF]

Sci Rep
Abdel-Nasser M, Fouda A, Abdel-Maksoud G.   +2 more
europepmc   +1 more source