Association between dynamic digital radiography findings and post-extubation respiratory deterioration: A retrospective exploratory analysis of a prospectively collected ICU cohort. [PDF]
PLoS OneKomatsu S +4 more
europepmc +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Sustainable closed-loop supply chain management for a two-warehouse system with trade-credit and emissions constraints under dynamic demand. [PDF]
Sci RepVishnoi M, Deepi D, Singh SR, Sarkar B.
europepmc +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
No More False Alert: Contrastive Learning for Predicting Health Deterioration from Imbalanced Care Records. [PDF]
Sensors (Basel)Kaneko H, Inoue S.
europepmc +1 more source
Time Dependent Deterioration of the X-Ray Dental Diagnostic Equipment
Statistics presented by NMS GRUPA Ltd. demonstrates that the Trophy ELITYS (25%) (further in text – ELITYS) is the most popular dental x-ray with high frequency and the Trophy IRIX 70 (13%) (further in text – IRIX 70) – with half-period generators in ...
Šneiders, Maksims +3 more
core
A Spatio-Temporal Bayesian Network Classifier for Understanding Visual Field Deterioration
, 2005 Progressive loss of the field of vision is characteristic of a number of eye diseases such as glaucoma which is a leading cause of irreversible blindness in the world. Recently, there has been an explosion in the amount of data being stored on patients
Liu, X +3 more
core
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Development and validation of three risk prediction models for clinical deterioration of patients after craniotomy: a retrospective cohort study in China. [PDF]
BMJ OpenXu L +5 more
europepmc +1 more source
Postoperative Late Hearing Deterioration in Cholesteatoma with Labyrinthine Fistulas
BACKGROUND: A labyrinthine fistula is a severe complication of middle ear cholesteatoma that can cause profound sensorineural hearing loss and vertigo. However, there is no consensus regarding the transition to postoperative hearing.
Yutaka Yamamoto +5 more
core +1 more source