Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Evaluation of effects of autologous fat grafting on aesthetic outcomes in breast reconstruction following mastectomy: Effects of reconstruction type and prior radiotherapy exposure. [PDF]
Omar S +5 more
europepmc +1 more source
Proceedings of symposium on deterioration of underground assets
SIGLEAvailable from British Library Lending Division - LD:84/33171(Proceedings) / BLDSC - British Library Document Supply CentreGBUnited ...
Institution of Water Engineers and Scientists, London (United Kingdom)
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E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Association Between the COGAS Score and Delayed Neuropsychiatric Sequelae After Acute Carbon Monoxide Poisoning. [PDF]
Lee SC, Ahn GJ.
europepmc +1 more source
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Association between packed red blood cell transfusion and clinical deterioration in neonatal necrotizing enterocolitis: a systematic review and meta-analysis. [PDF]
Huang J, Gao Q, Xu Z, Wang H.
europepmc +1 more source
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Endogenous Recovery of Fasting C-Peptide Decreases Progression of Sudomotor Small-Fibre Dysfunction in Adults With Diabetes: A Real-World Cohort Study. [PDF]
Cai Q +5 more
europepmc +1 more source
In Japan, the aging of public facilities constructed during the period of high economic growth is progressing. It is expected that huge renewal investment will concentrate in the future.
佐藤, 吉宏 +4 more
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