Results 91 to 100 of about 2,054,327 (318)

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Endomysial fibrosis, rather than overall connective tissue content, is the main determinant of conduction disturbances in human atrial fibrillation [PDF]

, 2022
Bart Maesen, Sander Verheule, Stef Zeemering, Mark La Meir, Jan Nijs, Stijn Lumeij, Dennis H. Lau, Mathieu Granier, Harry J.G.M. Crijns, Jos G. Maessen, Stefan Dhein, Ulrich Schotten   +11 more
openalex   +1 more source

Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target

FEBS Letters, EarlyView.
This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz, Milagros Siebeck Caturelli, Lina S. Lehmann, Florian Kurth, Alexander G. Maier, Kai Matuschewski   +5 more
wiley   +1 more source

Multiple gcd-closed sets and determinants of matrices associated with arithmetic functions

Open Mathematics, 2016
Let f be an arithmetic function and S= {x1, …, xn} be a set of n distinct positive integers. By (f(xi, xj)) (resp. (f[xi, xj])) we denote the n × n matrix having f evaluated at the greatest common divisor (xi, xj) (resp. the least common multiple [xi, xj]
Hong Siao, Hu Shuangnian, Hong Shaofang
doaj   +1 more source

Inner Language Form as a Determinant of its Lexical Peculiarity (based on the Study Material of the Russian and the Teleut Languages Paroemia)

RUDN Journal of Language Studies, Semiotics and Semantics, 2019
In the present article we make an effort to develop the ideas of the Russian linguist G.P. Melnikov about the determinants of the language system in the context of his study about the dynamic language nature.
Elvira S. Denisova, Anastasia V. Proskurina   +1 more
doaj   +1 more source

Biophysical analysis of angiotensin II and amyloid‐β cross‐interaction in aggregation and membrane disruption

FEBS Letters, EarlyView.
Angiotensin II (AngII), a neuropeptide, interacts with amyloid‐β (Aβ), a key player in Alzheimer's disease. This study reveals that AngII reduces Aβ aggregation and membrane disruption in vitro. Biophysical assays and molecular modeling suggest AngII binds disordered Aβ forms, potentially modulating early amyloidogenic events and contributing to ...
Mohsen Habibnia, Eric Catalina‐Hernandez, Maialen Cabrerizo‐Idiazabal, Ramon Barnadas‐Rodríguez, Mario Lopez‐Martin, Alex Peralvarez‐Marin   +5 more
wiley   +1 more source

Determinants and Inverses of Ppoeplitz and Ppankel matrices

Special Matrices, 2018
In this paper, we consider two kinds of special matrices, which are called Ppoeplitz matrix and Ppankel matrix. The idea of matrix transformation is used to compute the determinants and inverses of the Ppoeplitz matrix and the Ppankel matrix.
Zuo Baishuai, Jiang Zhaolin, Fu Deqian
doaj   +1 more source

Determinants of spatial variability of air pollutant concentrations in a street canyon network measured using a mobile laboratory and a drone

, 2022
Leena Järvi, Mona Kurppa, Heino Kuuluvainen, Topi Rönkkö, Sasu Karttunen, Anna Balling, Hilkka Timonen, Jarkko V. Niemi, Liisa Pirjola   +8 more
openalex   +1 more source

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

FEBS Letters, EarlyView.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer, Matheus Felipe Santos, Maurício Mazzine Filho, Gabriela Oliveira Castro, Agustín Hernández, Manoel Aparecido Peres, Alejandro Miguel Katzin, Marcell Crispim   +7 more
wiley   +1 more source

The coherence between PSMC6 and α-ring in the 26S proteasome is associated with Alzheimer’s disease

Frontiers in Molecular Neuroscience
Alzheimer’s disease (AD) is a heterogeneous age-dependent neurodegenerative disorder. Its hallmarks involve abnormal proteostasis, which triggers proteotoxicity and induces neuronal dysfunction.
Jing Xiong, Xinping Pang, Xianghu Song, Lin Yang, Chaoyang Pang   +4 more
doaj   +1 more source