Results 141 to 150 of about 6,635,178 (304)
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
A Canonical Quadratic Form on the Determinant Line of a Flat Vector Bundle [PDF]
, 2017 We introduce and study a canonical quadratic form, called the torsion quadratic form, on the determinant line of the cohomology of a flat vector bundle over a closed oriented odd-dimensional manifold.
Braverman, Maxim, Kappeler, Thomas
core
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Entrevista com Paulo Eduardo Arantes
, 2011 A revista Trans/Form/Ação publica neste número a entrevista com o filósofo Paulo Eduardo Arantes, professor aposentado do Departamento de Filosofia da Universidade de São Paulo.
Trans/Form/Ação, Revista
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The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
, 2011 A Trans/Form/Ação associa-se ao pesar de toda a comunidade filosófica brasileira pelo passamento recente do Professor Doutor Valerio Rohden, um dos fundadores, ex-Presidente e membro da Sociedade Kant Brasileira, além de personagem emblemática no âmbito ...
Trans/Form/Ação, Revista
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An application of the dieudonné determinant: Detecting non-tame automorphisms
, 2008 We show how to detect non-tame automorphisms by using a criterion which is based on the Dieudonné determinant and we construct some specific non-tame automorphisms of free metabelian Lie algebras and free Lie algebras of the form F/?m(F)'.
Özkurt Z., Ekici N.
core +1 more source