Results 141 to 150 of about 4,022 (258)

Closing the Gate Before the Horse is out of the Barn: A Model to Effectively Predict the First Fall in Patients with Parkinson's Disease

open access: yesMovement Disorders Clinical Practice, EarlyView.
Abstract Background Most fall‐prediction models in Parkinson's disease (PD) rely on prior falls, limiting prevention. The Waiting Room of the Future (WROTF) platform collects standardized motor and cognitive measures during routine visits, integrated into electronic health records (EHR).
Saar Anis   +5 more
wiley   +1 more source

Post-COVID-19 social determinants of health and quality of life: a longitudinal study. [PDF]

open access: yesRev Esc Enferm USP
Florencio SSG   +10 more
europepmc   +1 more source

Rare‐Variant Burden across Lysosomal Genes Implicates Sialylation and Ganglioside Metabolism in Parkinson's Disease

open access: yesMovement Disorders, EarlyView.
Abstract Background Lysosomal dysfunction is central to Parkinson's disease (PD) pathogenesis, with GBA1 representing the strongest established genetic risk factor. Numerous other genes involved in lysosomal sphingolipid, glycosphingolipid, and ceramide metabolism have been proposed as contributors to PD, highlighting the need for genetic analyses ...
Konstantin Senkevich   +21 more
wiley   +1 more source

A Phase 1 Study of Convection‐Enhanced Delivery of Intraputaminal AAV2‐GDNF in Advanced Parkinson's Disease

open access: yesMovement Disorders, EarlyView.
Abstract Background Parkinson's disease (PD) is a progressive neurodegenerative disorder. Neurotrophic therapeutic approaches have been limited in part by incomplete delivery to the putamen. We developed image‐guided convection‐enhanced delivery with real‐time monitoring to improve intraputaminal distribution of neurotrophic gene therapy. Objectives To
John D. Heiss   +10 more
wiley   +1 more source

[2027: A new year for a new epidemiological study of chronic obstructive pulmonary disease in Spain]. [PDF]

open access: yesOpen Respir Arch
Soriano JB   +4 more
europepmc   +1 more source

Redefining CHI3L1: Therapeutic Opportunities at the Crossroads of Immune Suppression and Disease Progression

open access: yesMedicinal Research Reviews, EarlyView.
ABSTRACT Chitinase‐3‐like‐1 (CHI3L1, also known as YKL‐40) has been recognized as a biomarker of inflammation and tissue remodeling and has now emerged as a pseudoenzymatic immune checkpoint. Recent structural, immunological, and translational studies redefine it as an active regulator of immune suppression rather than a passive disease marker. Despite
Kirti Upmanyu   +2 more
wiley   +1 more source

[Therapeutic Nursing Support and Psychotherapy in Childhood and Youth Obesity: AEESME's Public Health Approach']. [PDF]

open access: yesAten Primaria
Aguilera-Serrano C   +3 more
europepmc   +1 more source

1D Pre‐Acquisition Navigator Correcting Respiratory‐Induced Field Fluctuations in Multi‐Echo Gradient‐Echo Imaging of the Thoracic Spinal Cord

open access: yesMagnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose In the spinal cord (SC), multi‐echo gradient echo (ME‐GRE) increases gray (GM) and white matter (WM) contrast and improves sensitivity to lesions in people with multiple sclerosis (pwMS). However, SC ME‐GRE is susceptible to breathing‐induced field fluctuations, causing ghosting artifacts and signal loss.
Alicia E. Cronin   +13 more
wiley   +1 more source

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