Results 81 to 90 of about 356,920 (284)

Gut Bacteria Improve Depressive Symptoms by Degrading Cortisol into Androgen

Advanced Science, EarlyView.
Chronic stress is an important risk factor for stress‐related disorders such as depression. Stress hormone cortisol is essential for the pathogenesis of stress‐related disorders such as depression. Some gut microbiota degraded cortisol, and improve depressive symptoms.
Xiong Wang, Qing Wu, Hao‐Long Zeng, Yin Shen, Hong‐Han Zhang, Jun Gong, Qi Zhang, Jia‐Zhao Xie, Da‐Wei Ye, Zi‐Yong Sun, Zhong‐Chun Liu, Li‐Ming Cheng, Di Li   +12 more
wiley   +1 more source

Discovery of a Novel and Potent Kir4.1 Inhibitor as a Safe and Rapid‐Onset Antidepressant Agent in Mice

Advanced Science, EarlyView.
The preferred derivative JX3212 demonstrates strong inhibitory activity against Kir4.1 with favorable druggability and shows significant antidepressant efficacy in vivo. Abstract Major depressive disorder is a serious psychiatric disorder for which novel and fast‐acting antidepressants are required.
Sisi Wang, Xiaoyu Zhou, Mengdan Li, Chao Zhang, Haiyan Xu, Jingyi He, Li Zhan, Yueling Gu, Hao Gu, Tianyu Tu, Hanfang Liu, Taotao Lu, Yueming Zheng, Jian Li, Zhaobing Gao, Yixiang Xu   +15 more
wiley   +1 more source

Los determinantes sociales de la salud en la etapa neoliberal: un abordaje de las desigualdades desde la economía política

Ensayos de Economía, 2021
Los determinantes sociales explican la mayor parte de las inequidades de salud. Uno de los principales determinantes que identifica la Organización Mundial de la Salud es la desigual distribución de los ingresos.
Mariano Treacy
doaj  

Ferroptosis‐Mediated Hippocampal Neuronal Loss Post‐mTBI: Chromatin Accessibility Profiling and Single‐Nucleus Transcriptomics

Advanced Science, EarlyView.
Hippocampal single ‐nucleus transcriptomes and chromatin accessibility after mild traumatic brain injury reveal dentate granule neuron vulnerability driven by ferroptosis. The c‐Jun–Tmsb4x–Slc2a2 axis modulates lipid peroxidation and iron dysregulation.
Manrui Li, Qiuyun Yang, Shengqiu Qu, Yang Chen, Yang Shen, Yang Xu, Xilong Lin, Yihan Sun, Ying Chen, Meili Lv, Lin Zhang, Zengqiang Yuan, Weibo Liang, Xiameng Chen   +13 more
wiley   +1 more source

Relación de los determinantes sociales y el índice de higiene oral simplificado (IHOS), en los niños del cantón Manta en 2024

Revista Científica Especialidades Odontológicas UG
Los determinantes sociales de la salud integran la causalidad múltiple en el proceso salud enfermedad. La placa bacteriana desempeña un papel fundamental en el desarrollo de la caries y las enfermedades periodontales.
Juan Vasconez Salazar, Juan Sierra Zambrano   +1 more
doaj   +1 more source

Factores determinantes en la eficacia del Viral Mobile Marketing [PDF]

, 2015
This objective of this study is to analyze the factors determining the effectiveness of Viral Mobile Marketing. It deals with the effects of personalization on grabbing attention in an environment considered private, taking into account factors such as ...
Aguado Guadalupe, Guadalupe, García García, Alberto   +1 more
core   +2 more sources

CLinNET: An Interpretable and Uncertainty‐Aware Deep Learning Framework for Multi‐Modal Clinical Genomics

Advanced Science, EarlyView.
Identifying disease‐causing genes in neurocognitive disorders remains challenging due to variants of uncertain significance. CLinNET employs dual‐branch neural networks integrating Reactome pathways and Gene Ontology terms to provide pathway‐level interpretability of genomic alterations.
Ivan Bakhshayeshi, Mohammad Mahdi Hosseini, Ahmadreza Argha, Roxana Zahedi, Nigel H. Lovell, Hamid Alinejad‐Rokny   +5 more
wiley   +1 more source

Situación alimentaria y nutricional en Colombia desde la perspectiva de los determinantes sociales de la salud

Perspectivas en Nutrición Humana, 2013
La Organización Mundial de la Salud ha propuesto el marco teórico de los determinantes sociales de la salud como campo para la investigación y la acción, con el objetivo de disminuir las inequidades en la situación de salud entre regiones, países, grupos
Luz Stella Álvarez Castaño, Elsury Johanna Pérez Isaza   +1 more
doaj  

Determinantes para a implementação de um projeto social

Motriz. Revista de Educação Física. UNESP, 2010
This research investigated the main facilitators and barriers for the implementation of a social project in Curitiba, the Community School Program, and for the participation of children in the program. The research was qualitative and the data was collected through observations and open interviews with 65 Program agents (coordinators, teachers, student
Souza, Doralice Lange de, Vialich, Andrea Leal, Eiras, Suélen Barboza, Mezzadri, Fernando Marinho   +3 more
openaire   +4 more sources

IGF‐1 Deficiency Serves as an Integrated Biomarker Pathogenic Driver and Predictor in Poor Ovarian Response

Advanced Science, EarlyView.
IGF‐1 deficiency underlies poor ovarian response (POR), as reduced levels in follicular fluid and granulosa cells impair antral follicle formation and compromise reproductive outcomes. Including IGF‐1 as a biomarker significantly enhances the accuracy of models predicting both PORrisk and pregnancy success.
Zhu Hu, Yuanyuan Yu, Guanyou Huang, Jinnan Li, Chao Yang, Aizhuan Long, Jia Tang, Tengxiang Chen, Shuyun Zhao, Tuo Zhang   +9 more
wiley   +1 more source