Results 91 to 100 of about 2,911,566 (241)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Fetal Brain Tumor Harboring a Unique ROCK1::BRAF Fusion

Pediatric Blood &Cancer, EarlyView.
Marllon Cindra Sant'Ana, Mariana Maschietto, Daniela Paz Leal, Ricardo de Santos de Oliveira, Mayara Ferreira Euzébio, Antonio Carlos dos Santos, Luciano Neder, Carlos Alberto Scrideli, Elvis Terci Valera   +8 more
wiley   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Multimorbidity and its correlates in middle-aged and older adults in a city of North India

Journal of Family Medicine and Primary Care
Context: Multimorbidity (MM), defined as the presence of two or more chronic health conditions in an individual, can be more burdensome than single chronic disease.
Asra Saqib, Tabassum Nawab, Anees Ahmad, Najam Khalique   +3 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Trends in influenza vaccination and its determinants among pregnant French women between 2015 and 2020: A single-center study

Human Vaccines & Immunotherapeutics
In 2016, only 7% of French women had received an influenza vaccination during their pregnancy. In this vaccine-averse country, the possibility of reaching the rates of 50% observed in other countries remains unknown.
Khadija Alaoui, Sophie Vanderstichele, Stéphanie Bartolo, Yamina Hammou, Véronique Debarge, Rodrigue Dessein, Karine Faure, Damien Subtil   +7 more
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Evidence on Determinants of Foreign Investments: the Case of Three European Regions. A revised Version [PDF]

This study aims at analysing the determinants of foreign direct investment (FDI) inflows for a group of European regions. The originality of this approach lies in the use of disaggregated data by sector at regional level.
Lionel Artige, Rosela Nicolini
core  

Determinants of Statin Initiation Among Adult Diabetic Patients in Bonga, Ethiopia

Diabetes, Metabolic Syndrome and Obesity, 2020
Bezie Kebede zelalem, Desalegn Feyisa School of Pharmacy, College of Health Science, Mizan-Tepi University, Mizan-Teferi, EthiopiaCorrespondence: Bezie Kebede zelalem Tel +251 921279910Email beza.kebede21@gmail.comBackground: Diabetes mellitus (DM) is a ...
Kebede zelalem B, Feyisa D
doaj  

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source