Results 101 to 110 of about 1,261,069 (318)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Impact of Shared Bicycle Spatial Patterns During Public Health Emergencies: A Case Study in the Core Area of Beijing

ISPRS International Journal of Geo-Information
During public health emergencies, studying the travel characteristics and influencing factors of shared bicycles during different time periods on weekdays can provide valuable insights for urban transportation planning and offer recommendations for bike ...
Zheng Wen, Lujin Hu, Jing Hu
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

The path taken - developing organizational capacity for improving health equity in four Ontario health units

, 2015
National Collaborating Centre for Determinants of Health. (2015). The path taken: Developing organizational capacity for improving health equity in four Ontario health units. Antigonish, NS: National Collaborating Centre for Determinants of Health, St.
Daghofer, Diana
core  

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

The Learning Together Series : What is a Population Health Status Report and Why is it Important?

, 2012
National Collaborating Centre for Determinants of Health. (2012). Learning together: What is a Population Health Status Report and Why is it Important? Antigonish, NS: National Collaborating Centre for Determinants of Health, St.
Dyck, Lesley
core  

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Multimorbidity and its correlates in middle-aged and older adults in a city of North India

Journal of Family Medicine and Primary Care
Context: Multimorbidity (MM), defined as the presence of two or more chronic health conditions in an individual, can be more burdensome than single chronic disease.
Asra Saqib, Tabassum Nawab, Anees Ahmad, Najam Khalique   +3 more
doaj   +1 more source

Empower the Community : New Brunswick’s Approach to Overcoming Poverty

, 2012
National Collaborating Centre for Determinants of Health. (2012). Bridging the Gap between Research and Practice: Empower the Community-New Brunswick’s Approach to Overcoming Poverty.
Daghofer, Diana
core  

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source