Results 201 to 210 of about 733,924 (247)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Evaluating the association between upstream perceived individual and neighborhood determinants of health and intensity of breast cancer screening. [PDF]

Am J Epidemiol
Morley F, An A, Bea V, Tamimi RM, Kensler KH.   +4 more
europepmc   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Population health management within the primary care context - scoping review. [PDF]

Eur J Gen Pract
Schaubroeck E, Sessa G, De Maeseneer J, Willems S, Decat P.   +4 more
europepmc   +1 more source

Elements of social accountability in undergraduate health sciences curricula: A scoping review. [PDF]

S Afr J Physiother
Sujee L, Naidoo V, Myezwa H.
europepmc   +1 more source

An Orthogonal Electronic State View on Charge Delocalization and Transfer. [PDF]

J Phys Chem A
Folkestad SD, Høyvik IM.
europepmc   +1 more source

Toward Clinically Actionable Explainable AI in Pulmonary Arterial Hypertension: Endpoints, Calibration, and External Validation. Comment on Ledziński et al. Personalized Medicine in Pulmonary Arterial Hypertension: Utilizing Artificial Intelligence for Death Prevention. <i>J. Clin. Med.</i> 2025, <i>14</i>, 8325. [PDF]

J Clin Med
Pagnoni G, Vicenzi A, Coppi F.
europepmc   +1 more source

Multilevel factors influencing colorectal cancer screening adherence: A systematic literature review. [PDF]

PLoS One
Zubair NF, Mohammed Nawi A, Hassan MR, Daud A, Sarakarn P, Sutan R.   +5 more
europepmc   +1 more source

Determinants Associated With Pesticide Exposure in Patients With Head and Neck Cancer: Protocol for a Systematic Review.

JMIR Res Protoc
Sánchez-Ramírez GA, López Cabanillas Lomelí M, González-Martínez BE, Castro-Sánchez AE, De la Garza-Ramos MA, Cano-Verdugo G.   +5 more
europepmc   +1 more source