Results 31 to 40 of about 1,494 (234)
Determination of 5-azacitidine in human plasma by LC–MS/MS: application to pharmacokinetics pilot study in MDS/AML patients [PDF]
, 2023 International audienceAzacitidine (Vidaza®, AZA) is a mainstay for treating acute myeloid leukemia (AML) in patients unfit for standard induction and other myelodysplastic syndromes (MDS).
Donnette, Melanie +10 more
core +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
De la prise en compte des hétérogénéités morphologiques et structurales vers l'interprétation de la réactivité globale d'un hydroxyde d'aluminium [PDF]
, 2004 Interfaces mineral oxide-aqueous medium are essential for the understanding of the reactions which take place in natural environments. The objective of this study is to interpret a macroscopic behavior (such as surface charge or a sorption process) using
Jodin, Marie-Camille
core +2 more sources
Journal Africain de Technologie Pharmaceutique et BiopharmacieObjectif : La transmission mère-enfant du VIH durant l’allaitement est un problème de santé publique. Le but de cette étude était d’évaluer l’intérêt du suivi thérapeutique pharmacologique des femmes allaitantes sous ARV et leurs enfants à Bamako ...
Aboubacar Alassane Oumar +9 more
doaj +1 more source
INRAE Productions Animales, 2013 Le lait n’est pas tout à fait un aliment comme les autres puisqu’il est aussi produit par l’Homme. Cet aliment est indispensable à l’alimentation de l’enfant, car sa richesse nutritionnelle combinée à sa forme liquide en font une ration « tout en un ...
P. FAVERDIN, C. LEROUX
doaj +1 more source
Phosphoinositides and inositol phosphates as molecular glues
FEBS Letters, EarlyView.Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry +9 more
wiley +1 more source
Les droits collectifs des communautés de langue officielle en situation minoritaire au Canada [PDF]
, 2012 Je propose dans ce texte une réflexion sur les communautés de langue officielle en situation minoritaire au Canada ainsi que sur le concept d’autodétermination.
Michel Seymour, Seymour, Michel
core +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Apport de l’électro-imagerie en électrophysiologie cardiaque pour la prise en charge des troubles du rythme ventriculaire graves [PDF]
, 2021 Ventricular arrhythmia remains a major public health problem, in particular ventricular tachycardias. These arrhythmias most often occur in patients who previously presented a myocardial infarction.
Sellal, Jean-Marc
core