Results 41 to 50 of about 1,494 (234)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
PLANTES DE LA FAMILLE DES COMBRETACEAE UTILISÉES EN MÉDECINE TRADITIONNELLE ‚ SOURCES DE PRINCIPES ACTIFS ANTICANCÉREUX [PDF]
, 2020 Introduction : Au Mali il existe de nombreuses plantes de la famille des Combretaceae utilisées en médecine traditionnelle pour la prise en charge de nombreuses maladies dont les cancers. Objectif : Ce travail avait pour objectif d’étudier la phytochimie
Tienou, Marie Hortense
core
YIPFα1A expression is regulated by multilayered molecular mechanisms
FEBS Open Bio, EarlyView.YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji +2 more
wiley +1 more source
FEBS Open Bio, EarlyView.UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová +2 more
wiley +1 more source
Développement d'un système autonome de détection et de quantification des microARNs avec une plateforme nanofluidique pour la prise en charge du cancer du pancréas [PDF]
, 2018 85% des patients atteints de cancer du pancréas présentent au diagnostic des formes avancées de la maladie qui empêchent leur prise en charge thérapeutique efficace.
Cacheux, Jean
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Oil & Gas Science and Technology, 2006 Designing the foundations of offshore structures is a complex task, requiring both expert experience and the use of numerical models for safety insurance and design cost optimization.
Meimon Y.
doaj +1 more source
Arthritis Care &Research, EarlyView.Over the past 50 years, the science of pediatric rheumatology has grown exponentially due to an expansion in the understanding of complex rheumatic conditions and a surge in novel targeted therapeutics. Physician‐scientists in the field of pediatric rheumatology have played major roles in these advancements that have improved the care of children ...
Ekemini A. Ogbu +2 more
wiley +1 more source
Prise en charge des cancers bronchiques non à petites cellules oligométastatiques [PDF]
, 2020 The concept of oligometastatic disease applies to a subpopulation of patients with a low tumor burden clinically characterized by a limited number of metastases.
Dansin, Éric E. +6 more
core +1 more source
Arthritis Care &Research, EarlyView.Objective To investigate the association between rheumatoid arthritis (RA) and coronary artery calcium (CAC) prevalence, incidence, and progression over four years in adults without prior cardiovascular disease. Methods A case‐cohort study within the Brazilian Longitudinal Study of Adult Health (ELSA‐Brasil) included 585 participants (86 patients with ...
Patrícia Fonseca Estrada +7 more
wiley +1 more source
Physical activity and chronic diseases. Motivational principles contributing to a physically active behaviour [PDF]
, 2022 peer reviewedBien que l’activité physique soit perçue comme un agent thérapeutique efficace dans la prise en charge des maladies chroniques, la littérature rapporte un faible taux de participation aux programmes d’activité physique adaptée ainsi qu’un ...
Bodson, François, Mouton, Alexandre
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