ZRANB1 Is an EZH2 Deubiquitinase and a Potential Therapeutic Target in Breast Cancer
Cell Reports, 2018 Summary: Although EZH2 enzymatic inhibitors have shown antitumor effects in EZH2-mutated lymphoma and ARID1A-mutated ovarian cancer, many cancers do not respond because EZH2 can promote cancer independently of its histone methyltransferase activity. Here
Yun Huang, Xiaoping Xie, Shao-Cong Sun
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Mechanism of Lys6 poly-ubiquitin specificity by the L. pneumophila deubiquitinase LotA [PDF]
Molecular Cell, 2023 The versatility of ubiquitination to control vast domains of eukaryotic biology is due, in part, to diversification through differently linked poly-ubiquitin chains.
Justine V Nguyen +2 more
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The Deubiquitinase USP46 Is Essential for Proliferation and Tumor Growth of HPV-Transformed Cancers
Molecular Cell, 2018 The deubiquitinase USP46 is essential for proliferation and tumor growth of HPV-transformed cancers. High-risk Human Papilloma Viruses (HPV) cause cervical, anal and oropharyngeal cancers, unlike the low-risk HPVs, which cause benign lesions.
Anindya Dutta +2 more
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