Results 261 to 270 of about 27,265 (285)

The proteasome component PSMD14 drives myelomagenesis through a histone deubiquitinase activity.

Molecules and Cells, 2023
While 19S proteasome regulatory particle (RP) inhibition is a promising new avenue for treating bortezomib-resistant myeloma, the anti-tumor impact of inhibiting 19S RP component PSMD14 could not be explained by a selective inhibition of proteasomal ...
Lin He, Chunyu Yu, Sen Qin, Enrun Zheng, Xinhua Liu, Yanhua Liu, Shimiao Yu, Yang Liu, X. Dou, Zesen Shang, Yizhou Wang, Yue Wang, Xuehong Zhou, Boning Liu, Yuping Zhong, Zhiqiang Liu, Jin Lu, Luyang Sun   +17 more
semanticscholar   +1 more source

Modifying Deubiquitinases

Science, 2013
A technique for developing specific and potent enzyme inhibitors is validated on enzymes of the ubiquitin‑proteasome system.
openaire   +2 more sources

USP21 Deubiquitinase Regulates AIM2 Inflammasome Activation

The Journal of Immunology, 2021
Abstract Innate immune sensing of cytosolic DNA via absent in melanoma 2 (AIM2) is a key mechanism leading to inflammatory responses. As aberrant immune responses by dysregulated AIM2 are associated with autoinflammatory diseases, activation of the AIM2 inflammasome should be tightly controlled.
Yujin Hong, Seong-Ok Lee, Changhoon Oh, Kwonyoon Kang, Jeongmin Ryoo, Dongyoung Kim, Kwangseog Ahn   +6 more
openaire   +2 more sources

Emerging insights into bacterial deubiquitinases

Current Opinion in Microbiology, 2019
Bacterial pathogens utilize eukaryotic cellular systems in various ways for their own benefits. To counteract host immune responses and survive in cells, bacteria modify host signaling pathways. For this aim, they have evolved virulence secretion systems.
Tomoko Kubori, Tomoe Kitao, Hiroki Nagai
openaire   +2 more sources

Targeting Deubiquitinases in Cancer

2018
The ubiquitin-proteasome system (UPS) is a complex and robust metabolic pathway that contributes to the regulation of many key cellular processes including the cell cycle, cell division, and response to external stimuli. Ubiquitin ligases, which tag proteins with ubiquitin, are opposed by deubiquitinase enzymes (DUBs).
Joseph S, Bednash, Rama K, Mallampalli
openaire   +2 more sources

Regulation of deubiquitinase proteolytic activity

Current Opinion in Structural Biology, 2013
Deubiquitinases (DUBs) are proteolytic enzymes whose function is to oppose the process of the conjugation of ubiquitin to a specific substrate. This task is accomplished through an enzymatic cascade involving E1, E2, and E3 enzymes, which collectively produce a product that is either monoubiquitinated, or polyubiquitinated with multiple single ...
Oscar W, Huang, Andrea G, Cochran
openaire   +2 more sources

The First-in-class Deubiquitinase-targeting Chimera Stabilizes and Activates cGAS.

Angewandte Chemie
Deubiquitinase-targeting chimera (DUBTAC) is a promising technology for inducing targeted protein stabilization (TPS). Despite its therapeutic potential, very few proteins have been stabilized by DUBTACs to date.
Jian Jin, Zhijie Deng, Li Chen, Chao Qian, Jing Liu, Qiong Wu, Xiangyang Song, Yan Xiong, Zhen Wang, Xiaoping Hu, Hiroyuki Inuzuka, Yue Zhong, Yufei Xiang, Yindan Lin, Ngoc Dung Pham, Yi Shi, Wenyi Wei   +16 more
semanticscholar   +1 more source

Functional Dynamics of Deubiquitinase A

The FASEB Journal, 2022
Deubiquitinase A (DUBA) is an isopeptidase that cleaves K63‐linked and K48‐linked ubiquitin chains from substrate proteins. DUBA belongs to the ovarian tumor (OTU) subfamily of deubiquitinases (DUBs) and was initially identified as a negative regulator of the production of type I interferons.
Ying Li, Skyler Fether, Ashish Kabra
openaire   +1 more source

Gene expression control by protein deubiquitinases

Current Opinion in Genetics & Development, 2011
Protein ubiquitylation is involved in the regulation of virtually all aspects of eukaryotic cell biology, including gene expression. The central function of E3 ubiquitin ligases in target selection is well established. More recently, it has become appreciated that deubiquitylating enzymes (DUBs) are crucial components of ubiquitin-regulated cellular ...
Frappier, L, Verrijzer, Peter
openaire   +3 more sources

The Role of Deubiquitinases in Vascular Diseases

Journal of Cardiovascular Translational Research, 2019
Deubiquitinases (DUBs) are a major component of the ubiquitin-proteasome system in eukaryotic cells; the system plays a crucial role in many biological processes, such as inflammation, oxidative stress, and cell apoptosis, which are important in vascular biology and pathology. DUBs have drawn significant attention in recent years, and their function is
Biqing, Wang, Wenbin, Cai, Ding, Ai, Xu, Zhang, Liu, Yao   +4 more
openaire   +2 more sources