Results 271 to 280 of about 27,265 (285)
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Basis of the H2AK119 specificity of the Polycomb repressive deubiquitinase
Nature, 2023Weiran Ge +12 more
semanticscholar +1 more source
Regulation of Gli2 stability by deubiquitinase OTUB2
Biochemical and Biophysical Research Communications, 2018The transcription factor Gli2 plays crucial roles in the transduction of Hedgehog (Hh) signals, yet the mechanisms that control Gli2 degradation remain unclear. Here we have identified the eubiquitinating enzyme otubain2 (OTUB2) as a regulator of Gli2 protein degradation. We found that OTUB2 was coimmunoprecipitated with Gli2.
Xin-Yan, Li +7 more
openaire +2 more sources
Importance of deubiquitinases in zebrafish craniofacial development
Biochemical and Biophysical Research Communications, 2017Deconjugation of ubiquitin and/or ubiqutin-like modified substrates is essential to maintain a sufficient free ubiquitin within the cell. Deubiquitinases (DUBs) play a key role in the process. Besides, DUBs also play several important regulatory roles in cellular processes. However, our knowledge of their developmental roles are limited.
openaire +2 more sources
Deubiquitinase USP1 regulates sarbecovirus ORF6 protein function
Journal of VirologyABSTRACT SARS-CoV-2 belongs to the subgenus Sarbecovirus , which universally encodes the accessory protein ORF6. SARS-CoV-2 ORF6 is an antagonist of the interferon (IFN)-mediated antiviral response and plays an important role in viral infections.
Wenying Gao +7 more
openaire +2 more sources
The deubiquitinase USP7 regulates oxidative stress through stabilization of HO-1
Oncogene, 2022Ming Gao +13 more
semanticscholar +1 more source