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Spectral tracing of deuterium for imaging glucose metabolism [PDF]
Nature Biomedical Engineering, 2019 Cells and tissues often display pronounced spatial and dynamical metabolic heterogeneity. Common glucose-imaging techniques report glucose uptake or catabolism activity, yet do not trace the functional utilization of glucose-derived anabolic products ...
Lingyan Shi Or L Shi +2 more
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Deuterium in drug discovery: progress, opportunities and challenges
Nature Reviews Drug Discovery, 2023 Substitution of a hydrogen atom with its heavy isotope deuterium entails the addition of one neutron to a molecule. Despite being a subtle change, this structural modification, known as deuteration, may improve the pharmacokinetic and/or toxicity profile
Rita Maria Concetta Di Martino +2 more
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Recent Developments for the Deuterium and Tritium Labeling of Organic Molecules
Chemical Reviews, 2022 Organic compounds labeled with hydrogen isotopes play a crucial role in numerous areas, from materials science to medicinal chemistry. Indeed, while the replacement of hydrogen by deuterium gives rise to improved absorption, distribution, metabolism, and
Sara Kopf, Florian Bourriquen, Wu Li
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Nature Methods, 2019 Hydrogen deuterium exchange mass spectrometry (HDX-MS) is a powerful biophysical technique being increasingly applied to a wide variety of problems.
Glenn R Masson +2 more
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Proceedings of the National Academy of Sciences of the United States of America, 2020 Significance Stem xylem uptake and transport of plant source water is widely considered a critical component of the global water cycle. The deuterium signature of cryogenically extracted plant stem water (δ2Hstem_CVD) provides a useful means for studying
Yongle Chen +2 more
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Influence of the presence of deuterium on displacement damage in tungsten
Nuclear Materials and Energy, 2018 The influence of the presence of deuterium on displacement damage in tungsten is studied by implanting 20 MeV tungsten ions into displacement-damaged tungsten already containing 1.7 at.% deuterium.
T. Schwarz-Selinger +3 more
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Deuterium metabolic imaging (DMI) for MRI-based 3D mapping of metabolism in vivo
Science Advances, 2018 DMI shows metabolism of acetate and glucose in the brain and liver and reveals the Warburg effect in patients with brain tumors. Currently, the only widely available metabolic imaging technique in the clinic is positron emission tomography (PET ...
Henk M De Feyter +2 more
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Deuterium‐ and Tritium‐Labelled Compounds: Applications in the Life Sciences
Angewandte Chemie - International Edition, 2018 Volker Derdau, William J Kerr, Marc Reid
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Chemical Reviews, 2021 Solution-phase hydrogen/deuterium exchange (HDX) coupled to mass spectrometry (MS) is a widespread tool for structural analysis across academia and the biopharmaceutical industry.
Ellie I. James +4 more
semanticscholar +1 more source