Results 221 to 230 of about 276,793 (392)

Designing Enzymatic Reactivity with an Expanded Palette

open access: yesChemBioChem, EarlyView.
Innovation in biocatalysis is rapidly increasingly the diversity of catalytic reactivity that can be mediated by enzymes, addressing a key bottleneck for their widespread adoption in industrial chemical synthesis. A key approach to this is building enzymes with unnatural catalytic components that provide an expanded palette with new possibilities for ...
Reuben B. Leveson‐Gower
wiley   +1 more source

Selective [9‐15N] Guanosine for Nuclear Magnetic Resonance Studies of Large Ribonucleic Acids

open access: yesChemBioChem, EarlyView.
The small chemical shift anisotropy of nitrogen‐15 at the 9‐position in guanine (15N9‐G) leads to long T2 values and narrow NMR lines, particularly attractive to probe structure and dynamics of large (>200 nucleotide) ribonucleic acids (RNAs). RNAs regulate various cellular processes using malleable 3D structures, and understanding the factors that ...
Solomon K. Attionu   +5 more
wiley   +1 more source

Biosynthesis of Ephedrine is Initiated by Pyridoxal Phosphate‐Dependent Formation of Cathinone

open access: yesChemBioChem, Accepted Article.
Ephedra alkaloids possess some of the most basic structures of alkaloids. Despite their importance for human use and their commercial relevance, the biosynthesis of ephedra alkaloids has remained enigmatic. The predominant biosynthetic pathway in the literature proposes a thiamine‐dependent caboligation followed by a transaminase, although no candidate
Karina Witte   +4 more
wiley   +1 more source

Ru‐Catalyzed Alkene Hydrophosphination: Correlating Substrate Scope with An Outer‐Sphere Mechanism

open access: yesChemCatChem, EarlyView.
The rate of this outer‐sphere hydrophosphination catalyzed by a Cp*Ru complexdepends on the speed of either conjugate addition A delicate balance between these two possible turnover‐limiting steps is sensitive to the structure and electronic character of both the alkene and phosphine substrates, with big impacts on activity and selectivity.
Jin Yang   +3 more
wiley   +1 more source

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