Results 221 to 230 of about 291,001 (382)

Residual Chemical Shift Anisotropies in the Structure Determination of Small Molecules

open access: yesMagnetic Resonance in Chemistry, EarlyView.
Plasma neutrophil elastase(ELANE) was markedly elevated in patients with alcohol use disorder, indicating a dysregulated protease‐antiprotease inflammatory balance characterised by decreased SERPINA3. ELANE showed excellent diagnostic specificity(AUC = 0.8683), supporting its potential utility as a neuroinflammatory biomarker for AUD.
Nilamoni Nath   +3 more
wiley   +1 more source

Deuterium 1‐Channel Transmit/16‐Channel High Impedance Receive Array Combined With 16‐Channel 1H Dual‐Row Transceiver Array for 7 Tesla Brain Imaging

open access: yesMagnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose To develop and evaluate an 2H/1H coil configuration that enables deuterium metabolic imaging at 7 T while preserving high‐quality 1H anatomical imaging. Methods An 16‐channel 2H high‐impedance receive array was combined with a 2H transmit birdcage and a 16‐channel dual‐row 1H transceiver array.
Bei Zhang   +3 more
wiley   +1 more source

Colours of urban selection: carotenoid‐based signals reveal divergent urban/rural evolutionary trajectories in two closely related passerines

open access: yesOikos, EarlyView.
Urbanisation is a major driver of environmental change, reshaping ecological and evolutionary processes. Urban‐driven phenotypic differences are increasingly documented, but the underlying role of selection is still understudied. One pattern is the consistent reduction of carotenoid‐based plumage pigmentation in city birds.
Nicolas Bekka   +3 more
wiley   +1 more source

Disarming the Hsp70–Bim Alliance: Small‐Molecule and Peptidic Disruptors of a Chaperone‐Apoptotic Switch in Cancer

open access: yesChemistryOpen, EarlyView.
Targeting a nucleotide‐sensitive groove on Hsp70 that binds the Bim BH3 helix, we integrate structures, biophysics, and SAR from peptides, fragments, and phenalene‐dicarbonitrile “wedges.” These disrupt the Hsp70–Bim complex with sub‐µM cellular engagement and in vivo activity while sparing Hsp90/mortalin.
Emadeldin M. Kamel   +5 more
wiley   +1 more source

Mapping the structural dynamics of red- and blue-emitting beetle luciferases revealed by HDX-MS. [PDF]

open access: yesLife Sci Alliance
Kharbatli AR   +6 more
europepmc   +1 more source

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