Selective N‐Functionalization of Pyrazoles
European Journal of Organic Chemistry, Volume 29, Issue 40, 27 October 2026.This review traces the evolution of regioselective N‐functionalization strategies for pyrazoles, a key class of nitrogen heterocycles widely used in medicinal chemistry. Due to rapid tautomerism, N‐functionalization often lacks selectivity, leading to poor and unpredictable regioisomeric outcomes.
Lucas Popek +2 more
wiley +1 more source
Janus Reactivity of a Mononuclear Non‐Heme Iron(III)‐Peroxo Complex Toward Indole Oxidation
Angewandte Chemie, Volume 138, Issue 43, 19 October 2026.The iron(III)‐peroxo complex [FeIII(O2)(12‐TMC)]+ exhibits bifurcating pathways in indole oxidation. N─H indoles undergo N─H H‐atom abstraction, supported by a KIE of 5.2 for N─H/N–D 2,3‐dimethylindoles, whereas N‐methylindoles react via electrophilic addition of the iron‐peroxo group to the C2–C3 double bond of the indole ring, forming iron ...
Wenjuan Zhu +4 more
wiley +2 more sources
A Cytosine‑Bulged (3+1) Hybrid G‑Quadruplex Formed by the Chicken DNA Replication Origin
Chemistry – A European Journal, Volume 32, Issue 39, 22 October 2026.The first high‐resolution structure of an OGRE‐derived G‐quadruplex from the chicken β‐globin replication origin reveals an intramolecular three‐layer (3+1) hybrid fold with a cytosine bulge and an unprecedented 5'‐outer‐quartet anti guanine, creating a distinctive surface for molecular recognition.
Yingying You +13 more
wiley +1 more source
Dialkyl Ethers and Sacrificial Zinc: Oxide Synthons for Calcium tert‐Butoxide Formation
Angewandte Chemie, Volume 138, Issue 43, 19 October 2026.When treated with dialkyl ethers, [(BDI)Ca‐μ‐H‐Zn(t‐Bu)2(η6‐C7H8)] (BDI = HC{C(Me)NDipp}2 initiates a sequence of twofold ether dealkylation and oxide sequestration as tert‐butoxide in a process predicated on a combination of extreme basicity and a cooperative redox process administered by the dissimilar constituent metals. (Generative AI (ChatGPT) was
Kyle G. Pearce +3 more
wiley +2 more sources
Development of proteome-derived cyclic peptide libraries via ortho-phthalaldehyde-assisted cyclization. [PDF]
iScienceWei Y +6 more
europepmc +1 more source
Molybdooxaziridine Catalysis: Synthesis of α‐Hydroxysulfones From Styrenes Through an ATRA Process
European Journal of Organic Chemistry, Volume 29, Issue 39, 22 October 2026.This work has discovered that molybdooxaziridine catalysts promote the hydroxysulfonation of substituted α‐methyl‐styrenes using N‐Ts‐hydroxylamine as the nitrogen source. An atom‐transfer‐radical‐addition mechanism involving the stepwise addition of Ts and hydroxy radicals takes place.
Alyssa N. Singer, Gustavo Moura‐Letts
wiley +1 more source
Structural insights into antibody-antibody interactions in sandwich ELISA: implications for assay development and performance. [PDF]
Anal Bioanal ChemSu Y +11 more
europepmc +1 more source
Measurement of glycolysis with heavy water labeling. [PDF]
J Biol ChemZiari N, Hellerstein MK.
europepmc +1 more source
Angewandte Chemie International Edition, Volume 65, Issue 43, 19 October 2026.The straightforward conversion of alcohols to tertiary or secondary amines employing Nms‐amides in a single operation is described. The transformation features broad functional group tolerance and high stereospecificity, underscoring its utility in the synthesis of isotope‐labeled pharmaceuticals.
Jakub Brześkiewicz +3 more
wiley +1 more source
Water as a Sustainable Hydrogen Donor in Transfer Hydrogenation and Reduction Reactions. [PDF]
Chem RecPonnam D, Chen J, Fan B.
europepmc +1 more source