Results 61 to 70 of about 273,322 (239)

Pyridine-based strategies towards nitrogen isotope exchange and multiple isotope incorporation

Nature Communications
Isotopic labeling is at the core of health and life science applications such as nuclear imaging, metabolomics and plays a central role in drug development. The rapid access to isotopically labeled organic molecules is a sine qua non condition to support
Minghao Feng, Maylis Norlöff, Benoit Guichard, Steven Kealey, Timothée D’Anfray, Pierre Thuéry, Frédéric Taran, Antony Gee, Sophie Feuillastre, Davide Audisio   +9 more
doaj   +1 more source

An Injectable, Self‐Expanding Hemostatic Foam for Field‐Compatible Postpartum Hemorrhage Management

Advanced Science, EarlyView.
Postpartum hemorrhage is the leading cause of maternal death worldwide, yet many treatments are hard to use outside well‐equipped hospitals. This work introduces an easy‐to‐use device that rapidly delivers a degradable foam into the uterus. The foam stops bleeding through pressure and clotting support, offering a practical option for low‐resource ...
Charlotte Meyer, Noël Strasser, Ilakkiya Ravindrarajah, Elsa Wrenger, Kristian Ivkovic, Jan Ševčík, Sima Šarčević, Lenka Červenková, Jáchym Rosendorf, Václav Liška, Alexandre H. Anthis, Thomas Rduch, Inge K. Herrmann   +12 more
wiley   +1 more source

Bimodal Mesoporous Carbon Supported Palladium Clusters for Dehalogenative Deuteration of Aromatic Compounds

Journal of Isotopes
Dehalogenative deuteration represents a strategically important synthetic methodology for deuterium labeling，characterized by its precise positional selectivity and high isotopic incorporation efficiency.
Fengcheng YANG, Yutai WU, FuJia GAO, Guangping HAO   +3 more
doaj   +1 more source

Spatial Au+ Mapping Reveals a Self‐Amplifying Anti‐Tumor Immunity Loop Driven by Au(I) Complexes

Advanced Science, EarlyView.
The first report of spatial Au+ mapping of a representative gold complex (Au9). Macrophages, DCs, and tumor cells ranked as the top three in Au+ enrichment after Au9 treatment. Interestingly, Au9 treatment could induce ferroptosis and suppress cellular cholesterol, further eliciting a self‐amplifying anti‐tumor immunity loop.
Zhongren Xu, Zhiyue Fan, Lin Lv, Wei Lu, Zhenfan Wen, Wukun Liu   +5 more
wiley   +1 more source

Electrochemical cobalt-catalyzed semi-deuteration of alkynes to access deuterated Z-alkenes

Nature Communications
Deuterium labeling has found extensive applications across various research fields, including organic synthesis, drug design, and molecular imaging. Electrocatalytic semi-hydrogenation of alkynes offers a viable route for the synthesis of Z-alkenes, yet ...
Wen-Jie Feng, Zhe Chang, Xi Lu, Yao Fu
doaj   +1 more source

Remarkable functions of sn-3 hydroxy and phosphocholine groups in 1,2-diacyl-sn-glycerolipids to induce clockwise (+)-helicity around the 1,2-diacyl moiety: Evidence from conformation analysis by 1H NMR spectroscopy

Beilstein Journal of Organic Chemistry, 2017
Cell-membrane glycerolipids exhibit a common structural backbone of asymmetric 1,2-diacyl-sn-glycerol bearing polar head groups in the sn-3 position. In this study, the possible effects of sn-3 head groups on the helical conformational property around ...
Yoshihiro Nishida, Mengfei Yuan, Kazuo Fukuda, Kaito Fujisawa, Hirofumi Dohi, Hirotaka Uzawa   +5 more
doaj   +1 more source

Synthesis of 11, 12-2H2- and 11, 12-3H2-labeled chenodeoxycholic and lithocholic acids

Journal of Lipid Research, 1976
Deuterium- and tritium-labeled chenodeoxycholic acid and lithocholic were prepared by catalytic reduction of their respective Δ11 derivatives. Structures of the intermediates and their isotopic purity were verified by chemical ionization and electron ...
A E Cowen, A F Hofmann, D L Hachey, P J Thomas, D T Belobaba, P D Klein, L Tökes   +6 more
doaj   +1 more source

Effects of hydrogen plasma treatment on the electronic, optical, mechanical and chemical properties of Mo, Rh, Au, HOPG and Graphene [PDF]

, 2013
Interaction of ionic and atomic species of hydrogen isotopes (protium, deuterium and tritium) with transition metals and carbon materials is an important subject of research in the condensed matter physics and material science fields.
Eren, Baran
core   +1 more source

Sonogenetics Nanomedicine Activates the cGAS‐STING Pathway for Immunotherapy of Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
A HER3‐targeted sonogenetic lipid nanoparticle platform is developed for triple‐negative breast cancer therapy. An AI‐designed miniprotein inhibits HER3 signaling, while TRPV4 and NFAT‐responsive IL‐15 plasmids enable ultrasound‐controlled calcium signaling and cytokine expression. The system induces Ca2+ overload, ROS generation, mitochondrial damage,
Junya Song, Yan Liu, Shifeng Zhao, Cheng Zhu, Hongchang Guo, Jin Chang, Jun Kang   +6 more
wiley   +1 more source

Continuous-Flow Synthesis of Deuterium-Labeled Antidiabetic Chalcones: Studies towards the Selective Deuteration of the Alkynone Core

Molecules, 2016
Flow chemistry-based syntheses of deuterium-labeled analogs of important antidiabetic chalcones were achieved via highly controlled partial C≡C bond deuteration of the corresponding 1,3-diphenylalkynones.
Sándor B. Ötvös, Chi-Ting Hsieh, Yang-Chang Wu, Jih-Heng Li, Fang-Rong Chang, Ferenc Fülöp   +5 more
doaj   +1 more source