Results 31 to 40 of about 24,004 (264)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

LINFOMA DE ZONA MARGINAL ESPLÊNICA: O IMPACTO DE UM ADEQUADO EXAME FÍSICO NO DIAGNÓSTICO PRECOCE

Hematology, Transfusion and Cell Therapy
Introdução: O linfoma de zona marginal esplênica (LZME) constitui < 1% de todos os linfomas não Hodgkin. Caracteristicamente, este linfoma envolve baço e linfonodos hilares esplênicos.
BM Brandão, AJ Silva, E Kososki, RASR Junior, LM Almeida   +4 more
doaj   +1 more source

Sprachliche Etikette im polnisch-deutschen Vergleich lexikographisch erfasst

Linguistische Treffen in Wrocław, 2020
Höflichkeit ist ein Phänomen, das neulich immer häufiger auch sprachlich untersucht wird. Es handelt sich dabei um sprachliche Formen und Formeln, die in bestimmten Kommunikationssituationen ein-gesetzt werden können. Dabei spielt die sog.
Joanna Szczęk
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

FRAGEHANDLUNGEN IN AUTHENTISCHEN VORLESUNGSINTERAKTIONEN. Analysen, Beispiele und didaktische Potenziale für den studienbegleitenden DaF-Unterricht

Zeitschrift Korpora Deutsch als Fremdsprache
Unser Beitrag hat die didaktische Vermittlung des Hörverstehens in Vorlesungen zum Gegenstand. Im Rahmen eines bestehenden Projekts möchten wir aufzeigen, wie eine angemessene Didaktisierung auf der Basis eines fächerübergreifenden Vorlesungskorpus ...
Juliane Michelini, Martin Wichmann
doaj   +2 more sources

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

“SUBSTANTIV” ALS BESTIMMUNGSWORT ZUSAMMENGESETZTER ADJEKTIVE IN DER DEUTSCHEN RECHTSSPRACHE UND IHRE ÜBERSETZUNG IN DIE KROATISCHE SPRACHE [PDF]

Hum, 2013
In der Arbeit werden Arten von zusammengesetzten Adjektiven in der deutschen Sprache, bei denen das Bestimmungswort ein „Substantiv“ ist, untersucht. Bezüglich dessen, dass die deutsche Sprache eine Vorliebe für die Wortzusammensetzung im Allgemeinen,
Ružica Zeljko Zubac
doaj