Results 201 to 210 of about 431,758 (241)

A Unifying Thermodynamic Model for Phase Separation and Aging of Biopolymers

Advanced Science, EarlyView.
Phase separation and aging of intrinsically disordered proteins are placed in a unifying framework. A thermodynamically consistent time‐dependent version of associating‐polymer theory shows how the processes are intricately coupled. Assuming aging to occur through interacting sites resulting from reversible conformational transitions, the model ...
Jasper J. Michels, Joana Caria, Edward A. Lemke   +2 more
wiley   +1 more source

Dopamine depletion in Parkinson's increases directed but not random exploration. [PDF]

Sci Adv
Meder B, Sterf M, Wu CM, Guggenmos M.
europepmc   +1 more source

Cancer‐Associated BCL‐2 Mutants Reveal Mechanisms Towards Venetoclax Resistance

Advanced Science, EarlyView.
Venetoclax (VEN) resistance in chronic lymphocytic leukemia arises from diverse BCL2 mutations. We map mechanisms contributing to VEN resistance across common BCL‐2 variants. G101V and D103Y reduce drug binding and increase sequestration of pro‐apoptotic proteins. V156D blocks VEN allosterically.
Jonas Aufdermauer, Ian de Ridder, Mahjoobeh Ehsani, Marasim Khan, Justin Kale, Lukas P. Frenzel, David Andrews, Spyridoula Karamanou, Ana J. Garcia‐Saez, Geert Bultynck   +9 more
wiley   +1 more source

Complete genome sequence of <i>Serratia plymuthica</i> EIF4, a prodigiosin-producing isolate from freshwater. [PDF]

Microbiol Resour Announc
Friedrich I, Bornemann H, Wagner J, Karthikeyan V, Poehlein A, Daniel R.   +5 more
europepmc   +1 more source

Development and Applications of a Magnetism‐Aware General‐Purpose Atomic Cluster Expansion Potential for the Fe‐O‐H Ternary System

Advanced Science, EarlyView.
Hydrogen‐driven iron oxide reduction, water‐iron corrosion, and hydrogen embrittlement of metallic iron share the same Fe‐O‐H chemistry. A general‐purpose Atomic Cluster Expansion potential covers this chemistry across the full concentration range with explicit Ising‐like treatment of magnetism.
Baptiste Bienvenu, Mira Todorova, Jörg Neugebauer, Dierk Raabe, Matous Mrovec, Ralf Drautz   +5 more
wiley   +1 more source

The effect of data preprocessing on spike correlation analysis results. [PDF]

Biol Cybern
Oberste-Frielinghaus J, Ito J, Grün S.
europepmc   +1 more source

Millisecond Spin Relaxation Times of Distinct Electron and Hole Subensembles in MAxFA1−xPbI3 Perovskite Crystals

Advanced Science, EarlyView.
Mixed‐cation MAx${\rm MA}_x$ FA1−x${\rm FA}_{1-x}$ PbI3${\rm PbI}_3$ perovskite crystals reveal multiple discrete electron and hole spin subensembles associated with distinct localization environments. Optically detected magnetic resonance combined with resonant spin inertia uncovers carriers spin relaxation times reaching 2 ms and identifies nuclear ...
Rongrong Hu, Sergey R. Meliakov, Dmitri R. Yakovlev, Bekir Turedi, Maksym V. Kovalenko, Manfred Bayer, Vasilii V. Belykh   +6 more
wiley   +1 more source

Response to: Potential impact of NK-cell education on interferon efficacy in the ENDURE trial. [PDF]

Leukemia
Burchert A, Michel C.
europepmc   +1 more source

The Natural Product Corramycin Acts as a DNA Gyrase Poison and Overcomes Fluoroquinolone Resistance in Mycobacterium tuberculosis

Advanced Science, EarlyView.
Corramycin, a myxobacterial natural product antibiotic, exhibits potent bactericidal activity against multidrug‐resistant Mycobacterium tuberculosis. The compound hijacks bacterial transporters such as BacA and OppABCD to enter the cell and inhibits DNA synthesis through a previously unrecognized mode of DNA gyrase poisoning, locking the enzyme in an ...
Franziska Fries, Jennifer Herrmann, Michael Dal Molin, Yaëlle Wormser, Timo Risch, Yunsheng Gao, Gareth Prosser, Francesca Gubellini, Ariel Mechaly, Joshua B. Wallach, Anthony Castro, Arka Banerjee, Sari Rasheed, Alexander Horn, Mathias Müsken, Michael Kurz, Lindsay Sonnenkalb, Viola Dreyer, Stefan Niemann, Sönke Andres, Dirk Schnappinger, Uli Kazmaier, Norbert Reiling, Rolf Müller, Jan Rybniker, Stéphanie Petrella   +25 more
wiley   +1 more source

Three-year-old Children Make Explicit Metacognitive Judgments - If Asked Appropriately. [PDF]

Dev Sci
Meyer MM, Proft M, Engelmann J, Rakoczy H.   +3 more
europepmc   +1 more source