Results 101 to 110 of about 878,178 (411)

Bad Banks: The German scheme. [PDF]

open access: yes
Bad Bank; Bankenpolitik; Bankenkrise; Deutschland;
Lehment, Harmen
core  

Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry

open access: yesMolecular Oncology, EarlyView.
Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson   +11 more
wiley   +1 more source

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu   +11 more
wiley   +1 more source

The empirical relevance of minimum wages for the low-wage sector [PDF]

open access: yes
Niedriglohn, Mindestlohn, Wirtschaftlichkeit, Arbeitsplatz, Deutschland, Low wages, Minimum wage, Economic effectiveness, Job ...
Joachim Ragnitz, Marcel Thum
core  

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

open access: yesMolecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani   +14 more
wiley   +1 more source

Übergabequalität bei papierbasierter vs. elektronischer Pflegedokumentation: Eine quantitative Prä-Post-Studie

open access: yesGMS Medizinische Informatik, Biometrie und Epidemiologie
Um der Vielzahl an Herausforderungen des Gesundheitswesens im 21. Jahrhundert zu begegnen, greifen immer mehr Krankenhäuser auf digitale Dokumentationssysteme zurück.
Schießer, Sophia   +2 more
doaj   +1 more source

Paradigmen Kultureller Differenz und Hybriditaet

open access: yes, 2004
About the book: Zwar ist in den letzten Jahren der Konsens gewachsen, dass Deutschland ein Einwanderungsland ist, aber der Blick auf Migranten hat sich dadurch nicht wesentlich geändert. Auf der Basis des Paradigmas kultureller Differenz gelten sie nach
Erel, Umut
core  

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

open access: yesMolecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez   +17 more
wiley   +1 more source

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