Results 101 to 110 of about 465,241 (309)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

On the Economic Costs of the Spanish Flu Pandemic in Germany: An attempt at Assessing GNP Lost for 1918

Jahrbuch für Wirtschaftsgeschichte
Evidence on the economic costs of the Spanish flu pandemic between 1918 and 1920 in Germany is still scarce. An analysis of the second-largest German sickness fund at the time, which covered mineworkers in the Ruhr area, helps assess two types of short ...
Jopp Tobias A.
doaj   +1 more source

Warum Deutschland? [PDF]

, 2013
WARUM DEUTSCHLAND? Warum Deutschland? / Scholz, Antonia (Rights reserved) (-
Scholz, Antonia
core  

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Opferkonkurrenzen

S: I. M. O. N., 2019
1992 beschloss die Regierung der Bundesrepublik Deutschland, den Opfern des Völkermordes an den Sinti und Roma ein eigenes Denkmal zu widmen. Mitten in Berlin, nahe des ehemaligen Reichstagsgebäudes, wurde im Oktober 2012 das von dem Künstler Dani ...
Karola Fings
doaj  

Deutschland Deutschland über alles

, 2022
»Deutschland, Deutschland über alles«: Zitat aus dem Refrain des Lieds der Deutschen (Deutschlandlied). Text: August Heinrich Hoffmann von Fallersleben (1841), Musik: Joseph Haydn. Die Melodie stammt ursprünglich aus dem 1797 entstandenen Kaiserlied Haydns, der offiziellen Volkshymne Gott erhalte Franz, den Kaiserfür den damaligen römisch-deutschen ...
Straub, Wolfgang, Dürr, Claudia, Raunig, Elisabeth   +2 more
openaire   +1 more source

Klarheit und gute Nachbarschaft : Christen und Muslime in Deutschland ; eine Handreichung des Rates der EKD

, 2006
[hrsg.
Evangelische Kirche in Deutschland
core  

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

„Rücken“ kostet pro Jahr 11,6 Milliarden Euro

Monitor Versorgungsforschung
Mit den seit 2019 jährlich erscheinenden Gesundheitsatlas-Ausgaben des Wissenschaftlichen Instituts der AOK (WIdO) wird die Gesundheitssituation aller Einwohner:innen in den 400 Landkreisen und Städten Deutschlands transparent gemacht.
Peter Stegmaier
doaj   +1 more source