Results 181 to 190 of about 683,224 (393)

Volkshochschulen im Kontext beruflicher Weiterbildung. Einblicke aus der Programmforschung anhand von Einrichtungen in Deutschland [PDF]

open access: yesMagazin erwachsenenbildung.at
Volkshochschulen sind die bedeutendste Institution öffentlich geförderter, kommunaler Erwachsenen- und Weiterbildung in Deutschland. Diesen Stellenwert haben sie aufgrund ihrer flexiblen Institutionalform und ihrer flexiblen Bildungsplanung, die es ...
Marion Fleige   +5 more
doaj  

Evaluation of KRAS and NRAS mutations in metastatic colorectal cancer: an 8‐year study of 10 754 patients in Turkey

open access: yesMolecular Oncology, EarlyView.
This nationwide study evaluated KRAS and NRAS mutations in 10 754 Turkish patients with metastatic colorectal cancer. The results revealed a mutation frequency of 51.1%, with 46.6% having KRAS mutations, 4.5% having NRAS mutations, and 48.5% being wild‐type for both.
Gozde Kavgaci   +6 more
wiley   +1 more source

Nach 1995 deutliche Wachstumsschwäche der deutschen Wirtschaft im internationalen Vergleich [PDF]

open access: yes
Im Folgenden werden ausgewählte Ergebnisse einer neuen Datenquelle zur Messung von Wachstum und Produktivität im internationalen Vergleich präsentiert. Die Informationen decken den Zeitraum von 1970 bis 2004 ab.
Bernd Görzig, Martin Gornig
core  

Loss of proton‐sensing GPR4 reduces tumor progression in mouse models of colon cancer

open access: yesMolecular Oncology, EarlyView.
G protein‐coupled receptor 4 (GPR4) is a pH‐sensing receptor activated by acidic pH. GPR4 expression is increased in patients with inflammatory bowel disease who are at high risk of developing colorectal cancer. In mouse models, loss of GPR4 attenuated tumor progression. This correlated with increased IL2 and natural killer cell activity.
Leonie Perren   +16 more
wiley   +1 more source

Hartz IV – Welfare to Work in Germany [PDF]

open access: yes
Workfare, Wohlfahrtstheorie, Arbeitslosigkeit, Arbeitslosenversicherung, Deutschland, Welfare economics, Unemployment, Unemployment insurance ...
Wolfgang Ochel
core  

TRPM8 levels determine tumor vulnerability to channel agonists

open access: yesMolecular Oncology, EarlyView.
TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo   +18 more
wiley   +1 more source

Selective Immigration Policies: Point System versus Auction Model [PDF]

open access: yes
Einwanderung, Einwanderungsrecht, Migrationspolitik, Deutschland, Immigration, Immigration law, Migration policy ...
Wolfgang Ochel
core  

The anticancer effect of the HDAC inhibitor belinostat is enhanced by inhibitors of Bcl‐xL or Mcl‐1 in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine   +10 more
wiley   +1 more source

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