Results 221 to 230 of about 953,705 (390)

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

[Residents training in Austria and Germany : Cross-border perspectives: career paths and opportunities]. [PDF]

Pathologie (Heidelb)
Ormanns S, Brunner-Véber A, Günther M.
europepmc   +1 more source

Genscheren-Forschung an der menschlichen Keimbahn: Plädoyer für eine neue Debatte auch in Deutschland [PDF]

, 2017
Bettina Schöne-Seifert
openalex   +1 more source

Europaweite Anwendung des SVAT-Modells AMBAV unter Verwendung von ICON-EU-Daten als Input: Fallstudie für Deutschland und Belgien

, 2021
Kristin Haßelbusch, Antje Lucas-Moffat
openalex   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

[Current evidence on intraoperative ultrasound : A position paper of the German Society for Ultrasound in Medicine (DEGUM)]. [PDF]

Chirurgie (Heidelb)
Tesch C, Liesenfeld L, Crisan D, Endtricht S, Fries U, Großer K, Hackl C, Heinen C, Hillert C, Hoffmann S, Huettl F, Jo P, König R, Krishnabhakdi S, Kruck S, Künzel J, Meimarakis G, Pedro MT, Pfister K, Rass K, Schopf S, Symeou L, Thiel JT, Tost F, Weimann A, Hahn M.   +25 more
europepmc   +1 more source

Zur Identität von Neoascis unifasciata (Strobl, 1898) - mit einem Schlüssel für die in der Bundesrepublik Deutschland nachgewiesenen Arten der Gattung Neoascia Williston 1886 (Diptera: Syrphidae)

, 1986
W Barkemeyer, Camilla Clausen
openalex   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Erratum zu: Die Maßnahme Blaufeuer für Erwerbstätige mit psychischer Belastung und gleichzeitiger Arbeitsplatzproblematik – Wird die Zielgruppe erreicht? [PDF]

Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz
Schuler M, Gerlich C, Leven L, Renz S, Pamperin I, Vorsatz N, Vogel H.   +6 more
europepmc   +1 more source

Eignung von Wetterindexversicherungen zur Risikoreduzierung in Ackerbaubetrieben : eine Analyse in Regionen Deutschlands mit moderaten Standortbedingungen

, 2019
Juliane Amelie Clarissa Urban
openalex   +1 more source