Results 71 to 80 of about 869,633 (359)
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Sachstandsbericht: Strukturierte medizinische Ersteinschätzung in Deutschland (SmED)
Notfall + Rettungsmedizin, 2019 Ab 01.01.2020 müssen die Kassenärztlichen Vereinigungen eine telefonische Ersteinschätzung im 24/7-Betrieb anbieten. Ziel ist die Ersteinschätzung der Dringlichkeit akuter Beschwerden und eine Vermittlung an die angemessene Versorgungsstufe.
D. Graf von Stillfried +2 more
semanticscholar +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Freiwilliges Engagement in Deutschland
Empirische Studien zum bürgerschaftlichen Engagement, 2022 J. Simonson, C. Vogel, C. Tesch-Römer
semanticscholar +1 more source
National Institutional Systems in Global Competition and the Inertia of German Labour Market Institutions [PDF]
Arbeitsverwaltung, Internationaler Wettbewerb, Deutschland, Welt, Labour administration, Global competition, Germany ...
Wolfgang Ochel
core
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
RUDN Journal of Public Administration, 2016 Im Artikel wird wenig besprochenes in deutscher wissenschaftlicher Literatur Problem der Verbindung zwischen Arbeitslosigkeit und der sozialen Aktivitt der Bundesbrger betrachtet.
Evgenia E Koppel, Galina I Bykova
doaj +1 more source
A Concept for a New Budget Rule for Germany [PDF]
Öffentlicher Haushalt, Öffentliche Finanzplanung, Deutschland, Public Budget, Public Budgeting ...
Christian Kastrop +2 more
core
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source