Results 221 to 230 of about 4,721 (285)

AlphaBind, a domain-specific model to predict and optimize antibody-antigen binding affinity. [PDF]

MAbs
Agarwal AA, Harrang J, Noble D, McGowan KL, Lange AW, Engelhart E, Lahman MC, Adamo J, Yu X, Serang O, Minch KJ, Wellman KY, Younger DA, Lopez RM, Emerson RO.   +14 more
europepmc   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Revisiting Mission‐Oriented Cancer Research to tackle the increasing burden of cancer in Europe–a policy perspective

Molecular Oncology, EarlyView.
Translational cancer research and its implementation through competitively selected Comprehensive Cancer Centers across Europe should be the primary policy focus for addressing the increasing cancer burden in Europe and counteract the present main strategy to convert cancer to a chronic disease.
Manuel Heitor, Julio Celis, Ulrik Ringborg   +2 more
wiley   +1 more source

Applying computational protein design to therapeutic antibody discovery - current state and perspectives. [PDF]

Front Immunol
Bielska W, Jaszczyszyn I, Dudzic P, Janusz B, Chomicz D, Wrobel S, Greiff V, Feehan R, Adolf-Bryfogle J, Krawczyk K.   +9 more
europepmc   +1 more source

Biophysical and Structural Characterization of Antibody-Drug Conjugates. [PDF]

Cancers (Basel)
Mariano IP, Nath A.
europepmc   +1 more source

Accelerating antibody discovery and optimization with high-throughput experimentation and machine learning. [PDF]

J Biomed Sci
Matsunaga R, Tsumoto K.
europepmc   +1 more source

Leveraging artificial intelligence in antibody-drug conjugate development: from target identification to clinical translation in oncology. [PDF]

NPJ Precis Oncol
Lu Y, Huang W, Li Y, Xu Y, Wei Q, Sha C, Guo P.   +6 more
europepmc   +1 more source

Energy-guided combinatorial co-optimization of antibody affinity and stability

Tennenhouse A, Mechaly A, Oldham RJ, Henry J, Elliott IG, Kim J, Sirkis YF, Gaiduk S, Christ D, Cragg MS, Fleishman SJ.   +10 more
europepmc   +1 more source