Results 191 to 200 of about 23,042,479 (320)

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Computational design of therapeutic antibodies with improved developability: efficient traversal of binder landscapes and rescue of escape mutations. [PDF]

MAbs
Dreyer FA, Schneider C, Kovaltsuk A, Cutting D, Byrne MJ, Nissley DA, Kenlay H, Marks C, Errington D, Gildea RJ, Damerell D, Tizei P, Bunjobpol W, Darby JF, Drulyte I, Hurdiss DL, Surade S, Wahome N, Pires DEV, Deane CM.   +19 more
europepmc   +1 more source

Determinants of Developability and Evolvability of Synthetic Miniproteins as Ligand Scaffolds. [PDF]

J Mol Biol, 2023
McConnell A, Batten SL, Hackel BJ.
europepmc   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

Self-Developable Surface Relief Photoimaging Generated by Anionic UV-Curing of Epoxy Resins

, 2009
Ken'ichi Aoki, K. Ichimura
semanticscholar   +1 more source

How phagocytic cells kill bacteria: Lessons from a professional killer

FEBS Open Bio, EarlyView.
How phagocytic cells ingest and kill bacteria has been studied for more than a century, but many questions remain unanswered. The study of the amoeba Dictyostelium discoideum brings new answers, and new questions. Professional phagocytic cells such as neutrophils and macrophages, as well as free‐living soil amoebae like Dictyostelium discoideum, employ
Otmane Lamrabet, Pierre Cosson
wiley   +1 more source

Developable surfaces in hyperbolic space [PDF]

Pacific Journal of Mathematics, 1975
openaire   +2 more sources

AI-Driven De Novo Binder Design: From Structure Prediction to Closed-Loop Optimization. [PDF]

Comput Struct Biotechnol J
Li X, Fan Z, Yang J, Jiang R, Cao F, Li J, Xie D, Meng X, Sun M, Wang L.   +9 more
europepmc   +1 more source

Effect of terahertz irradiation on DNA damage repair in living cells

FEBS Open Bio, EarlyView.
We investigated the effect of terahertz (THz) wave irradiation on DNA double‐strand break (DSB) repair in living cells. We found that THz irradiation enhanced DSB repair at specific frequencies, whereas heat treatment inhibited it, indicating that this effect is nonthermal and frequency‐specific.
Yuya Ueno, Shota Yamazaki, Hiromichi Hoshina, Masahiko Harata   +3 more
wiley   +1 more source

In Situ Growth of Mushroom-Shaped Adhesive Structures on Flat/Curved Surfaces via Electrical Modulation. [PDF]

Adv Sci (Weinh)
Tian H, Li Y, Wang D, Chen Q, Jiang Y, Liu T, Li X, Wang C, Chen X, Shao J.   +9 more
europepmc   +1 more source