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The Developing Brain [PDF]

open access: possible, 2006
This chapter reviews the development of the normal brain primarily as studied with nuclear imaging methods, with an emphasis on radiopharmaceutical-based methods [positron emission tomography (PET), single photon emission computed tomography (SPECT), and PET-computed tomography (PET-CT)].
Lorcan A. O’Tuama, Paul R. Jolles
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Reelin and brain development

Nature Reviews Neuroscience, 2003
Over the last 50 years, the reeler mutant mouse has become an important model for studying normal and abnormal development in the cerebral cortex and other regions of the brain. However, we are only just beginning to understand the actions of reelin — the protein that is affected by the reeler mutation — at the molecular and cellular level. This review
André M. Goffinet, Fadel Tissir
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The developing brain

Early Years Educator, 2012
The growth and development of the human brain generally follows set patterns, although timescales will vary, but it is still vital that we provide activities that stimulate and strengthen neural pathways.
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The Developing Brain.

Archives of Neurology, 1965
This monograph The Developing Brain is a report of a symposium held at Galesburg State Research Hospital, Illinois, April 1963. Forty-eight scientists contributed. The symposium is a correlation of the structural, functional, chemical, cognitive, and behavioral fields of the central nervous system in relation to its phylo-ontogenetic unfolding.
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Epileptogenesis in the developing brain

2013
The neonatal brain has poorly developed GABAergic circuits, and in many of them GABA is excitatory, favoring ictogenicity. Frequently repeated experimental seizures impair brain development in an age-dependent manner. At critical ages, they delay developmental milestones, permanently lower seizure thresholds, and can cause very specific cognitive and ...
Amy S Wasterlain   +3 more
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Neurovesicles in Brain Development

Cellular and Molecular Neurobiology, 2016
Long before the nervous system is organized into electrically active neural circuits, connectivity emerges between cells of the developing brain through extracellular signals. Extracellular vesicles that shuttle RNA, proteins, and lipids from donor cells to recipient cells are candidates for mediating connectivity in the brain. Despite the abundance of
David M. Feliciano, Mary C. Morton
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Iodine and brain development

BioFactors, 1999
AbstractThe development of the brain is critically dependent on an adequate supply of iodine. Iodine is an integral part of thyroid hormone, which acts on brain development by regulating the expression of target genes. The active thyroid hormone, T3, is generated in part in the thyroid gland, but about 80% of T3 in brain is formed locally from T4 ...
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Fetuin‐A in the developing brain

Developmental Neurobiology, 2012
The serum protein fetuin‐A is essential for mineral homeostasis and shows immunomodulatory functions, for example by binding to TGF superfamily proteins. It proved neuroprotective in a rat stroke model and reduced lethality after systemic lipopolysaccharide challenge in mice. Serum fetuin‐A concentrations are highest during intrauterine life. Different
Joachim Weis   +6 more
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Sleep and Brain Development

Clinics in Perinatology, 2006
Historically, researchers studying the field of sleep have been divided into two main groups. The first group of sleep studies was based on behaviors and behavioral sleep. The second group of researchers based their studies on electroencephalogram EEG patterns and changes.
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Development of the Brain

1983
The nervous system develops from primitive cells, the neuroblasts. When a neuroblast matures and forms a nerve cell, it loses its ability to divide again. The transition from neuroblast to neuron occurs during foetal life. The total number of nerve cells in the central nervous system is fixed at this stage, since mature neurons generally cannot divide ...
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