Results 11 to 20 of about 1,745,656 (286)

Montelukast reduces grey matter abnormalities and functional deficits in a mouse model of inflammation-induced encephalopathy of prematurity

Journal of Neuroinflammation, 2022
Encephalopathy of prematurity (EoP) affects approximately 30% of infants born
Abi G. Yates, Elena Kislitsyna, Carla Alfonso Martin, Jiaying Zhang, Amy L. Sewell, Ane Goikolea-Vives, Valerie Cai, Lama F. Alkhader, Aleksander Skaland, Basil Hammond, Ralica Dimitrova, Dafnis Batalle, Cathy Fernandes, A. David Edwards, Pierre Gressens, Claire Thornton, Helen B. Stolp   +16 more
doaj   +1 more source

Characterisation of ASD traits among a cohort of children with isolated fetal ventriculomegaly

Nature Communications, 2023
Isolated fetal ventriculomegaly is the most common antenatally-diagnosed brain abnormality. Here, the authors show that isolated fetal ventriculomegaly is associated with autism spectrum disorder traits.
Vanessa Kyriakopoulou, Alice Davidson, Andrew Chew, Nidhi Gupta, Tomoki Arichi, Chiara Nosarti, Mary A. Rutherford   +6 more
doaj   +1 more source

The Neuroscience of Moral Judgment: Empirical and Philosophical Developments [PDF]

, 2022
We chart how neuroscience and philosophy have together advanced our understanding of moral judgment with implications for when it goes well or poorly.
Haas, Julia, Han, Hyemin, May, Joshua, Workman, Clifford I.   +3 more
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Cerebral organoids as tools to identify the developmental roots of autism

Molecular Autism, 2020
Some autism spectrum disorders (ASD) likely arise as a result of abnormalities during early embryonic development of the brain. Studying human embryonic brain development directly is challenging, mainly due to ethical and practical constraints.
Wai Kit Chan, Rosie Griffiths, David J. Price, John O. Mason   +3 more
doaj   +1 more source

Individual Assessment of Perioperative Brain Growth Trajectories in Infants With Congenital Heart Disease: Correlation With Clinical and Surgical Risk Factors

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023
Background Infants with congenital heart disease (CHD) are at risk of neurodevelopmental impairments, which may be associated with impaired brain growth.
Daniel Cromb, Alexandra F. Bonthrone, Alessandra Maggioni, Paul Cawley, Ralica Dimitrova, Christopher J. Kelly, Lucilio Cordero‐Grande, Olivia Carney, Alexia Egloff, Emer Hughes, Joseph V. Hajnal, John Simpson, Kuberan Pushparajah, Mary A. Rutherford, A. David Edwards, Jonathan O'Muircheartaigh, Serena J. Counsell   +16 more
doaj   +1 more source

Involvement of the JNK/FOXO3a/Bim Pathway in Neuronal Apoptosis after Hypoxic-Ischemic Brain Damage in Neonatal Rats. [PDF]

, 2015
c-Jun N-terminal kinase (JNK) plays a key role in the regulation of neuronal apoptosis. Previous studies have revealed that forkhead transcription factor (FOXO3a) is a critical effector of JNK-mediated tumor suppression.
Li, Deyuan, Li, Jinhui, Li, Xihong, Mu, Dezhi, Qu, Yi, Tang, Jun, Wu, Jinlin, Xiong, Tao, Zhang, Li   +8 more
core   +2 more sources

Spatiotemporal dynamics of the postnatal developing primate brain transcriptome. [PDF]

, 2015
Developmental changes in the temporal and spatial regulation of gene expression drive the emergence of normal mature brain function, while disruptions in these processes underlie many neurodevelopmental abnormalities.
Amaral, David G, Bakken, Trygve E, Bennett, Jeffrey L, Bernard, Amy, Bertagnolli, Darren, Geschwind, Daniel H, Lee, Chang-Kyu, Lein, Ed S, Luo, Rui, Miller, Jeremy A, Parikshak, Neelroop N, Smith, Kimberly A, Sunkin, Susan M   +12 more
core   +1 more source

Ligand and Carbohydrate Engagement (LACE) Assay and Fluorescence Quantification on Murine Neural Tissue

Bio-Protocol, 2021
The interaction between cell surface heparan sulphate and diffusible ligands such as FGFs is of vital importance for downstream signaling, however, there are few techniques that can be used to investigate this binding event.
James Clegg, Thomas Pratt
doaj   +1 more source

Effect of schizophrenia common variants on infant brain volumes: cross-sectional study in 207 term neonates in developing Human Connectome Project

Translational Psychiatry, 2023
Increasing lines of evidence suggest deviations from the normal early developmental trajectory could give rise to the onset of schizophrenia during adolescence and young adulthood, but few studies have investigated brain imaging changes associated with ...
Hai Le, Konstantina Dimitrakopoulou, Hamel Patel, Charles Curtis, Lucilio Cordero-Grande, A. David Edwards, Joseph Hajnal, Jacques-Donald Tournier, Maria Deprez, Harriet Cullen   +9 more
doaj   +1 more source

FetalGAN: Automated Segmentation of Fetal Functional Brain MRI Using Deep Generative Adversarial Learning and Multi-Scale 3D U-Net

Frontiers in Neuroscience, 2022
An important step in the preprocessing of resting state functional magnetic resonance images (rs-fMRI) is the separation of brain from non-brain voxels. Widely used imaging tools such as FSL’s BET2 and AFNI’s 3dSkullStrip accomplish this task effectively
Josepheen De Asis-Cruz, Dhineshvikram Krishnamurthy, Chris Jose, Kevin M. Cook, Catherine Limperopoulos   +4 more
doaj   +1 more source