Results 81 to 90 of about 925,172 (288)
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Use the information dimension, not the Hausdorff [PDF]
, 2005 Multi-fractal patterns occur widely in nature. In developing new algorithms to determine multi-fractal spectra of experimental data I am lead to the conclusion that generalised dimensions $D_q$ of order $q\leq0$, including the Hausdorff dimension, are ...
Roberts, A. J.
core +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
IEEE Access, 2019 Recently, instantaneous wave-free ratio (iFR) or diastolic pressure-ratio (dPR) have been used in practice. For these indices, the reliability of electrocardiography (ECG)-independent algorithm for pressure-only data is essential.
Ki Hong Choi +10 more
doaj +1 more source
Developing new algorithms for estimating river discharge from space [PDF]
Eos, Transactions American Geophysical Union, 2012 SWOT River Discharge Algorithms Workshop;Chapel Hill, North Carolina, 18–20 June 2012 Flow of water through rivers is a critical component of the global hydrologic cycle, yet present‐day discharge on many rivers remains poorly observed. The planned NASA/Centre National d'Études Spatiales (CNES) Surface Water and Ocean Topography (SWOT) satellite ...
Tamlin Pavelsky, Michael Durand
openaire +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Layered architecture for quantum computing
, 2012 We develop a layered quantum computer architecture, which is a systematic framework for tackling the individual challenges of developing a quantum computer while constructing a cohesive device design.
Alexei Yu. Kitaev +23 more
core +2 more sources
Symplectic discretization approach for developing new proximal point algorithm
Computational Optimization and Applications22 pages, 16 ...
Ya-xiang Yuan, Yi Zhang
openaire +2 more sources
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source