Results 101 to 110 of about 12,117,877 (287)

Development of isoform selective PI3-kinase inhibitors as pharmacological tools for elucidating the PI3K pathway

, 2012
Ian C. Bruce, Mohammed Shahid Akhlaq, Graham C. Bloomfield, Emma Budd, Brian J. Cox, Bernard Cuenoud, Peter M. Finan, Peter Gedeck, Julia Hatto, Judy Hayler, Denise Head, Thomas H. Keller, Louise Kirman, Catherine Leblanc, Darren Le Grand, Clive McCarthy, Desmond O’Connor, Charles Owen, Mrinalini S. Oza, Gaynor Pilgrim, Nicola E. Press, Lilya Sviridenko, Lewis Whitehead   +22 more
openalex   +1 more source

The downside of ‘inappropriate messaging’: new insight into the development of testicular germ cell tumours in young men? [PDF]

, 2013
Richard M. Sharpe, Rod T. Mitchell
openalex   +1 more source

Screening for lung cancer: A systematic review of overdiagnosis and its implications

Molecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto   +12 more
wiley   +1 more source

Development of QoS optimized routing using Artificial bee colony and TABU-GA with a mobile base station in Wireless Sensor Network

, 2019
Varsha Varsha, Manju Bala, Manoj Kumar, Neeraj Kumar   +3 more
openalex   +1 more source

Cajal Bodies Are Developmentally Regulated during Pollen Development and Pollen Tube Growth in Arabidopsis thaliana [PDF]

, 2013
Regina Scarpin, Lorena Sigaut, Lı́a I. Pietrasanta, Sheila McCormick, Binglian Zheng, Jorge Muschietti   +5 more
openalex   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

Government action needed to step up research and development for world’s most neglected diseases [PDF]

, 2005
Bernard Pécoul
openalex   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Impact of a spruce budworm outbreak in balsam fir and subsequent stand development over a 40-year period [PDF]

, 2008
David A. MacLean, Allison R Andersen
openalex   +1 more source