Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells
FEBS Letters, EarlyView.Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura +8 more
wiley +1 more source
EXPERIMENTAL POTASSIUM DEPLETION IN NORMAL HUMAN SUBJECTS. II. RENAL AND HORMONAL FACTORS IN THE DEVELOPMENT OF EXTRACELLULAR ALKALOSIS DURING DEPLETION* [PDF]
, 1959 Edward J. Huth +2 more
openalex +1 more source
The East Midlands public procurement opportunities plan [PDF]
, 2009 Public sector procurement activity accounts for a significant share of economic activity. This document sets out how the East Midlands can maximize the commercial benefits of these opportunities and contribute to the delivery of public policy in the ...
East Midlands Development Agency
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Bosonization Theory of Excitons in One-dimensional Narrow Gap Semiconductors [PDF]
, 2001 Excitons in one-dimensional narrow gap semiconductors of anti-crossing quantum Hall edge states are investigated using a bosonization method. The excitonic states are studied by mapping the problem into a non-integrable sine-Gordon type model.
Bird +4 more
core +1 more source
Cancer cell death induced by the NAD antimetabolite Vacor discloses the antitumor potential of SARM1
FEBS Letters, EarlyView.Vacor, a compound converted into the toxic metabolite Vacor adenine dinucleotide (VAD) by the nicotinamide salvage pathway enzymes NAMPT and NMNAT2, exhibits antitumor activity by inducing rapid and complete NAD depletion. We report that Vacor toxicity is limited to cell lines expressing high levels of SARM1, a NAD glycohydrolase.
Giuseppe Ranieri +5 more
wiley +1 more source
PRELIMINARY NOTE ON THE DEVELOPMENT OF PIROPLASMA CANIS IN THE TICK [PDF]
, 1907 S. R. Christophers
openalex +1 more source
, 2007 ICCD_newsletter_Winter_2008_PDF.pdf: 250 downloads, before Oct.
Institute for Community College Development
core +2 more sources
Protein kinase FAM20C—when subcellular localization matters
FEBS Letters, EarlyView.FAM20C is a Golgi‐resident kinase that phosphorylates proteins along the entire secretory pathway. The presence of potential FAM20C substrates in the cytoplasm or nucleus raises the question of how the kinase and its substrates encounter each other. Protein kinases achieve signaling specificity through consensus sequence recognition and subcellular ...
Francesca Noventa, Mauro Salvi
wiley +1 more source
On the uniform convergence of the developments in Bessel functions [PDF]
, 1911 Charles N. Moore
openalex +1 more source
Nutrition-sensitive value chains: A guide for project design [PDF]
, 2019 A first-of-its-kind, this new Guide from IFAD presents practical, step-by-step guidance for shaping value chain projects to improve nutrition. The Guide highlights challenges and opportunities in establishing nutrition-sensitive value chains (NSVCs) and ...
International Fund for Agricultural Development
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