Cyclic nucleotide signaling as a drug target in retinitis pigmentosa
FEBS Letters, EarlyView.Disruptions in cGMP and cAMP signaling can contribute to retinal dysfunction and photoreceptor loss in retinitis pigmentosa. This perspective examines the mechanisms and evaluates emerging evidence on targeting these pathways as a potential therapeutic strategy to slow or prevent retinal degeneration.
Katri Vainionpää +2 more
wiley +1 more source
Sustainable development in government : Wales 2009 [PDF]
, 2012 English language version of 'Cynaliadwyedd llywodraeth cynulliad : Cymru 2009'.The first assessment of the Welsh Assembly government's performance against its Green Dragon targets.Publisher ...
Sustainable Development Commission Wales
core
The Physiology of Growth in Apple Fruits II. Respiratory and Other Metabolic Activities as Functions of Cell Number and Cell Size in Fruit Development [PDF]
, 1951 RN Robertson, JF Turner
openalex +1 more source
Rewriting the dendritic cell code in cancer—from subset identity to immunotherapeutic design
FEBS Letters, EarlyView.Dendritic cells (DCs) play central roles in cancer immunity but are often subverted by the tumor microenvironment. This review explores the diversity of DC subsets, their functional plasticity, and emerging therapeutic strategies to reprogram DCs for enhanced antitumor responses, including vaccines, in vivo targeting, and DC‐based immunotherapies ...
Estevão Carlos Silva Barcelos +3 more
wiley +1 more source
Teacher Professional Development in Singapore: Depicting the Landscape [PDF]
Psychology, Society & Education, 2015 This article depicts the landscape of teacher professional development (PD) in Singapore, one of the world’s top-performing countries in education. We provide an overview of the resources available to the approximately 30,000 teachers within the 350 ...
Teacher Professional Development in Singapore: Depicting the Landscape +2 more
doaj
The development of the shoulder‐girdle of sus scrofa [PDF]
, 1920 Frank Blair Hanson
openalex +1 more source
FEBS Letters, EarlyView.Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu +17 more
wiley +1 more source
Regional innovation networks (iNets) for the East Midlands: prospectus for applicants [PDF]
, 2007 Prospectus for expressions of interest to establish regional innovation Networks (iNets) in priority sectors (healthcare, transport, environment and food and drink).
East Midlands Development Agency
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An examination of the effects of mechanical shocks and vibrations upon the rate of development of fertilized eggs [PDF]
, 1906 D. D. Whitney
openalex +1 more source
From omics to AI—mapping the pathogenic pathways in type 2 diabetes
FEBS Letters, EarlyView.Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan +2 more
wiley +1 more source