Results 141 to 150 of about 32,083,256 (335)

Transcriptome‐wide analysis of circRNA and RBP profiles and their molecular relevance for GBM

open access: yesMolecular Oncology, EarlyView.
CircRNAs are differentially expressed in glioblastoma primary tumors and might serve as therapeutic targets and diagnostic markers. The investigation of circRNA and RNA‐binding proteins (RBPs) interactions shows that distinct RBPs play a role in circRNA biogenesis and function.
Julia Latowska‐Łysiak   +14 more
wiley   +1 more source

SDC Supplier Obligation engagement project : process plan [PDF]

open access: yes, 2012
This process plan and timetable were used to form the basis of 'SDC Supplier Obligation project : household energy from 2011 : final report'.Publisher ...
Sustainable Development Commission
core  

Expert Consensus on Active Health Management of Short Stature Based on the Integration of Sports, Healthcare and Education(2025 Edition)

open access: yesXiehe Yixue Zazhi
Short stature is a disease that affects children's physical and psychological health, closely associated with lifestyle factors such as diet, physical activity, and sleep.
China Behavioral Medical Research Center for Growth and Development, Behavioral Medicine Branch of Chinese Medical Association Committee on Growth, Development and Metabolism, China Maternal and Child Health Research Association
doaj   +1 more source

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini   +10 more
wiley   +1 more source

The East Midlands public procurement opportunities plan [PDF]

open access: yes, 2009
Public sector procurement activity accounts for a significant share of economic activity. This document sets out how the East Midlands can maximize the commercial benefits of these opportunities and contribute to the delivery of public policy in the ...
East Midlands Development Agency
core  

Consensus on the Establishment and Operational Standards of Standardized Growth-and-Development Medical Centers Based on Active Health Principles (2025)

open access: yesXiehe Yixue Zazhi
With accelerated socioeconomic development and structural lifestyle changes, childhood and adolescent growth and developmental disorders in China have exhibited increasing complexity and a trend toward earlier onset, while the incidence of certain ...
China Behavioral Medical Research Center for Growth and Development, Behavioral Medicine Branch of Chinese Medical Association   +1 more
doaj   +1 more source

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan   +10 more
wiley   +1 more source

Elucidating prognostic significance of purine metabolism in colorectal cancer through integrating data from transcriptomic, immunohistochemical, and single‐cell RNA sequencing analysis

open access: yesMolecular Oncology, EarlyView.
Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim   +8 more
wiley   +1 more source

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