Results 121 to 130 of about 5,957,804 (303)

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Antimicrobial Resistance Development Pathways in Surface Waters and Public Health Implications. [PDF]

Antibiotics (Basel), 2022
Kusi J, Ojewole CO, Ojewole AE, Nwi-Mozu I.   +3 more
europepmc   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Same soybean policy, different responses of agricultural systems: Comparing effectiveness of cropping pattern adjusting in state farms and rural household farms of Heilongjiang, China

Geography and Sustainability
State farms, although a minority in China’s agricultural sector, play a critical role in regions like Heilongjiang, leading national food production. However, how state farms (SFs) and rural household farms (RFs) respond to food policies, especially the ...
Xi Chen, Jinwei Dong, Zhichao Li, Li Sun, Chuantao Ren, Guoming Du, Yuanyuan Di, Nanshan You, Xiaoyong Liao   +8 more
doaj   +1 more source

Development of Road Surface Detection Algorithm Using CycleGAN-Augmented Dataset. [PDF]

Sensors (Basel), 2021
Choi W, Heo J, Ahn C.
europepmc   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Development of a surface plasmon resonance biosensor for accurate and sensitive quantitation of small molecules in blood samples. [PDF]

J Pharm Anal, 2022
Qi M, Lv D, Zhang Y, Wang D, Chen X, Zhu Z, Hong Z, Chai Y, Zhang H, Cao Y.   +9 more
europepmc   +1 more source

Surface wind convergence as a short-term predictor of cloud-to-ground lightning at Kennedy Space Center: A four-year summary and evaluation [PDF]

Since 1986, USAF forecasters at NASA-Kennedy have had available a surface wind convergence technique for use during periods of convective development.
Holle, Ronald L., Lopez, Raul E., Nicholson, James R., Watson, Andrew I.   +3 more
core   +1 more source

Regulatory Cooperation, Regional Trade Agreements, and World Trade Law: Conflict or Complementarity? [PDF]

, 2014
Today, the growing and aging population, and the rise of new global threats on human health puts an increasing demand on the healthcare system and calls for preventive actions.
Howse, Robert
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source